Role of HLA-restricted T cells in colorectal cancer (Abstract in rivista)

Type

• Prodotto della ricerca (Classe)
• Abstract in rivista (Classe)

Label

• Role of HLA-restricted T cells in colorectal cancer (Abstract in rivista) (literal)

Anno

• 1996-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/0198-8859(96)84817-8 (literal)

Alternative label

• Berghella AM; Pellegrini P; Del Beato T; Adorno D; Casciani CU (1996)
  Role of HLA-restricted T cells in colorectal cancer
  
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Berghella AM; Pellegrini P; Del Beato T; Adorno D; Casciani CU (literal)

Pagina inizio

• 26 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ingentaconnect.com/content/els/01988859/1996/00000047/00000001/art84817 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 47 (literal)

Rivista

• Human immunology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• ITOI IFT (literal)

Titolo

• Role of HLA-restricted T cells in colorectal cancer (literal)

Abstract

• The role of the HLA-restricted T cells in the immune response to tumour is one of the major subject in the recent cancer research. The attention of cancer therapy has focused especially on the use of IL-2 cytokine, which, preferentially stimulates natural killer cells, whereas T cells are only temporarily activated. There is evidence that HLA-restricted T-cells play an important role in cancer therapy, and we have addressed this problem in colorectal cancer patients (np=36), compared to healthy subjects (nc=23), at systemic level by examining the proliferative response of PBMC to IL-2 and IL-2+antiCD3 monoclonal antibody, in correlation with the stage progression of the disease. The patients' proliferative response to IL-2 (p=0.35) and IL-2+antiCD3 (p=0.42) were not statistically different from those of the healthy subjects. In the evaluation of the patients' groups at the various stages, a decrease in the response to IL-2 was found (stage 1 n=6 -> stage IV n=13, p=0.0005). However, the addition of antiCD3 to IL-2 reversed this situation determining a significant increase in PBMC proliferative response (stage 1 n=6 -> stage IV n=13, p=0.0068). It would seem that there are faults at a level of mechanisms of the proliferative response of patients' PBMC to the IL-2 which increase with the stage progression and that these damages are eliminated by the costimulator effects of the signals produced by antiCD3. So, the IL-2 cytokine is a good stimulus for the patients' immune response at very early phase of colorectal cancer, whereas in the later stages the costimulator effect of antiCD3 towards IL-2 was needed. Our results support that HLA-restricted T-cells play an important role in the patients' immune response to tumour and the major goals in cancer therapy should be a better stimulation of T cells and a potentiation of HLA antigens expression at tumoural tissue level. (literal)

Autore CNR

• PATRIZIA PELLEGRINI (Unità di personale interno)
• TIZIANA DEL BEATO (Unità di personale interno)
• ANNA MARIA BERGHELLA (Unità di personale interno)

Incoming links:

Autore CNR di

• PATRIZIA PELLEGRINI (Unità di personale interno)
• ANNA MARIA BERGHELLA (Unità di personale interno)
• TIZIANA DEL BEATO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Human immunology (Rivista)