http://www.cnr.it/ontology/cnr/individuo/prodotto/ID175998
Amyloid beta-protein: physiological and toxicological role- Biophysical inquiry into ptotein aggregation and amyloid diseases. (Contributo in volume (capitolo o saggio))
- Type
- Label
- Amyloid beta-protein: physiological and toxicological role- Biophysical inquiry into ptotein aggregation and amyloid diseases. (Contributo in volume (capitolo o saggio)) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Alternative label
Di Carlo M.; Carrotta R.; Montana G.; Picone P. (2008)
Amyloid beta-protein: physiological and toxicological role- Biophysical inquiry into ptotein aggregation and amyloid diseases.
Transworld Research Network, Trivandrum (India) in Biophysical Inquiry into Protein Aggregation and Amyloid Diseases, 2008
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Di Carlo M.; Carrotta R.; Montana G.; Picone P. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume
- Biophysical Inquiry into Protein Aggregation and Amyloid Diseases (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Titolo
- Amyloid beta-protein: physiological and toxicological role- Biophysical inquiry into ptotein aggregation and amyloid diseases. (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#isbn
- 978-81-7895-354-0 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#curatoriVolume
- P.L. San Biagio; D. Bulone (literal)
- Abstract
- The amyloid ?-protein (A?) is the major
component of neuritic plaques that are the prominent
feature of Alzheimer's disease (AD). A? is a 39-42
amino acid peptide that can be accumulated extracellularly
and derives from multiple proteolytic
cleavage of a large transmembrane precursor, the
amyloid precursor protein (APP). It is widely accepted
that AD syndrome can be correlated to either altered
APP expression or proteolytic processing, or to
changes in A? stability and following aggregation.Although neuronal degeneration occurs near the amyloid plaques, some
studies have suggested that intermediates such as protofibrils and A?-derived
diffusible ligands (ADDLs) or simple oligomers are involved in AD
pathogenesis. Toxic properties for aggregates of different size have been
investigated and support the possibility that different pathways leading to
degeneration could be undertaken. Considering the important role played by
A? in AD, different strategies have been developed to target A? molecule in
potential therapeutic treatments. (literal)
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