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Short communication: The β-casein (CSN2) silent allele C1 is highly spread in goat breeds (Articolo in rivista)

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Short communication: The β-casein (CSN2) silent allele C1 is highly spread in goat breeds (Articolo in rivista) (literal)

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Stefania Chessa; Daniela Rignanese; Julia Küpper; Giulio Pagnacco; Georg Erhardt; Anna Caroli (2008)
Short communication: The β-casein (CSN2) silent allele C1 is highly spread in goat breeds
in Journal of dairy science; American Dairy Science Association-ADSA, Champaign (Stati Uniti d'America)
(literal)

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Stefania Chessa; Daniela Rignanese; Julia Küpper; Giulio Pagnacco; Georg Erhardt; Anna Caroli (literal)

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Stefania Chessa, Daniela Rignanese, Giulio Pagnacco - Dipartimento di Sclenze e Tecnologie Veterinarie per la Sicurezza Alimentare, Università degli Studi dl Milano, Via Trentacoste 2, Milano, 20134, Italy; Julia Küpper, Georg Erhardt - Institut für Tierzucht und Haustiergenetik, Justus-Liebig-Universität, Ludwigstr. 21 b, 35390 Gießen, Germany; Anna Caroli - Dipartimento di Scienze Biomediche e Blotecnologle, Università degli Studi di Brescia, Viale Europa 11, Brescia, 25123, Italy (literal)

Titolo

Short communication: The β-casein (CSN2) silent allele C1 is highly spread in goat breeds (literal)

Abstract

Several single nucleotide polymorphisms have been identified in the goat milk casein genes, most of them modifying the amino acid sequence of the coded protein. At least 9 variants have been found in goat β-CN (CSN2); 6 of them were characterized at the DNA level (A, A1, C, E, 0, and 0'), whereas the other 3 variants were described only at the protein level. The recently identified silent Al allele is characterized by a C->T transition at the 180th nucleotide of the ninth exon. In the present work, typing results from different breeds (3 Italian, 3 German, and a composite of African breeds for a total of 335 samples) demonstrated that the same mutation is carried by the CSN2*C allele. In addition, the T nucleotide at the 180th nucleotide of the ninth exon was always associated with CSN2*C in all the breeds analyzed. Thus, another silent allele occurs at goat CSN2 and can be named CSN2*C1. The much wider distribution of C1 with respect to the A1 allele indicates that the single nucleotide polymorphisms characterizing the silent mutation originated from CSN2*C. A method for the identification of this allele simultaneously with 5 of the 6 DNA-characterized alleles is also proposed. The mutation involved codifies for the same protein of the C allele; nevertheless, its location in the 3' untranslated region of the gene might affect the specific casein expression. (literal)

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