Advances in parallel screening of drug candidates (Articolo in rivista)

Type
Label
  • Advances in parallel screening of drug candidates (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Bergese P.; Cretich M.; Oldani C.; Oliviero G.; Di Carlo G.; Depero L.E.; Chiari M. (2008)
    Advances in parallel screening of drug candidates
    in Current medicinal chemistry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bergese P.; Cretich M.; Oldani C.; Oliviero G.; Di Carlo G.; Depero L.E.; Chiari M. (literal)
Pagina inizio
  • 1706 (literal)
Pagina fine
  • 1719 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 15 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Chimica del Riconoscimento Molecolare (ICRM), CNR Università di Brescia (literal)
Titolo
  • Advances in parallel screening of drug candidates (literal)
Abstract
  • In the hit to lead process, a drug candidate is selected from a set of potential leads by screening its binding with potential targets. This review focuses on the lead identification assays that employ a bio-chemical or bio- physical test to detect molecular recognition events between proteins and small molecules in a parallel format. These tests require either the lead or the target immobilization followed by incubation with the set of potential interaction partners and detection of a signal related to the target- ligand binding. In the first part of the review the different detection strategies amenable for drug screening are discussed. In the second part, a review of immobilization approaches for leads or targets, allowing the parallel screening of arrays of molecules, is presented. (literal)
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Autore CNR

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