The Mammalian Passenger Protein TD-60 Is an RCC1 Family Member with an Essential Role in Prometaphase to Metaphase Progression (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The Mammalian Passenger Protein TD-60 Is an RCC1 Family Member with an Essential Role in Prometaphase to Metaphase Progression (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Cristiana Mollinari1, 5, Caroline Reynaud1, 5, Stephanie Martineau-Thuillier1, Solange Monier2, Sylvie Kieffer3, Jerome Garin3, Paul R Andreassen4, Annick Boulet2, Bruno Goud2, Jean-Philippe Kleman1, Robert L Margolis1 (2003)
  The Mammalian Passenger Protein TD-60 Is an RCC1 Family Member with an Essential Role in Prometaphase to Metaphase Progression
  in Developmental cell
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cristiana Mollinari1, 5, Caroline Reynaud1, 5, Stephanie Martineau-Thuillier1, Solange Monier2, Sylvie Kieffer3, Jerome Garin3, Paul R Andreassen4, Annick Boulet2, Bruno Goud2, Jean-Philippe Kleman1, Robert L Margolis1 (literal)

Pagina inizio

• 297 (literal)

Pagina fine

• 307 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• Developmental cell (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Institut de Biologie Structurale J-P Ebel, CEA-CNRS, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France 2 Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 5, France 3 Département Réponse et Dynamique Cellulaires, CEA Grenoble, 38054 Grenoble Cedex 9, France 4 Dana-Farber Cancer Institute, M640, 44 Binney Street, Boston, MA 02115 USA (literal)

Titolo

• The Mammalian Passenger Protein TD-60 Is an RCC1 Family Member with an Essential Role in Prometaphase to Metaphase Progression (literal)

Abstract

• Passenger proteins migrate from inner centromeres to the spindle midzone during late mitosis, and those described to date are essential both for proper chromosome segregation and for completion of cell cleavage. We have purified and cloned the human passenger protein TD-60, and we here report that it is a member of the RCC1 family and that it binds preferentially the nucleotide-free form of the small G protein Rac1. Using siRNA, we further demonstrate that the absence of TD-60 substantially suppresses overall spindle assembly, blocks cells in prometaphase, and activates the spindle assembly checkpoint. These defects suggest TD-60 may have a role in global spindle assembly or may be specifically required to integrate kinetochores into the mitotic spindle. The latter is consistent with a TD-60 requirement for recruitment of the passenger proteins survivin and Aurora B, and suggests that like other passenger proteins, TD-60 is involved in regulation of cell cleavage. (literal)

Autore CNR

• CRISTIANA MOLLINARI (Unità di personale interno)

Insieme di parole chiave

• Keywords of "The Mammalian Passenger Protein TD-60 Is an RCC1 Family Member with an Essential Role in Prometaphase to Metaphase Progression" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• CRISTIANA MOLLINARI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Developmental cell (Rivista)

Insieme di parole chiave di

• Keywords of "The Mammalian Passenger Protein TD-60 Is an RCC1 Family Member with an Essential Role in Prometaphase to Metaphase Progression" (Insieme di parole chiave)