http://www.cnr.it/ontology/cnr/individuo/prodotto/ID17496
Amyloid-beta peptide affects the oxygen dependence of erythrocyte metabolism: A role for caspase 3 (Articolo in rivista)
- Type
- Label
- Amyloid-beta peptide affects the oxygen dependence of erythrocyte metabolism: A role for caspase 3 (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Alternative label
Clementi M.E., Giardina B., Colucci D., Galtieri A., Misiti F. (2007)
Amyloid-beta peptide affects the oxygen dependence of erythrocyte metabolism: A role for caspase 3
in International journal of biochemistry & cell biology
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- Clementi M.E., Giardina B., Colucci D., Galtieri A., Misiti F. (literal)
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- Clementi M.ECNR, Istituto di Chimica del Riconoscimento Molecolare (ICRM), L.go F. Vito n.1, CAP 00168 Rome, Italy
Giardina B: CNR and Biochemistry and Clinical Biochemistry Institute, Catholic University, School of Medicine, L.go F. Vito n.1, CAP 00168 Rome, Italy
Colucci D:Organic and Biological Chemistry Department, University of Messina, Messina, Italy
Galtieri A:Organic and Biological Chemistry Department, University of Messina, Messina, Italy
Misiti F: Health and Motor Sciences Department, University of Cassino, V.le Bonomi, 03043 Cassino (FR), Italy (literal)
- Titolo
- Amyloid-beta peptide affects the oxygen dependence of erythrocyte metabolism: A role for caspase 3 (literal)
- Abstract
- Human erythrocyte metabolism is modulated by the cell oxygenation state. Among other mechanisms, competition of deoxyhemoglobin and some glycolytic enzymes for the cytoplasmic domain of band 3 is probably involved in modulation. This metabolic modulation is connected to variations in intracellular NADPH and ATP levels as a function of the oxygenation state of the cell, and, consequently, it should have physiologic relevance. The present study investigates the effect of amyloid-beta peptide exposure on this metabolic modulation and its relationship with the activity of erythrocyte caspase 3. Metabolic differences between erythrocytes incubated at high and low oxygen saturation disappear following to 24 h exposure to amyloid-beta peptide. Western blotting analysis shows that caspase 3 is concurrently activated. Pre-incubation of amyloid-beta peptide-treated erythrocytes with a specific inhibitor of caspase 3, partially restores the oxygen-dependent modulation. This finding suggests that human erythrocytes following to exposure to amyloid-beta peptide show it complete loss of the oxygen-dependent metabolic modulation, which is partially restored by caspase 3 inhibitor-treatment. (literal)
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