Rational design of shepherdin, a novel anticancer agent (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Rational design of shepherdin, a novel anticancer agent (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Alternative label

• Plescia J.; Salz W.; Xia F.; Pennati M.; Zaffaroni N.; Daidone M.G.; Meli M.; Dohi T.; Fortugno P.; Nefedova Y.; Gabrilovich D.I.; Colombo G.; Altieri D.C. (2005)
  Rational design of shepherdin, a novel anticancer agent
  in Cancer cell (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Plescia J.; Salz W.; Xia F.; Pennati M.; Zaffaroni N.; Daidone M.G.; Meli M.; Dohi T.; Fortugno P.; Nefedova Y.; Gabrilovich D.I.; Colombo G.; Altieri D.C. (literal)

Pagina inizio

• 457 (literal)

Pagina fine

• 468 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 7 (literal)

Rivista

• Cancer cell (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Anticancer agents that selectively kill tumor cells and spare normal tissues are urgently needed. Here, we engineered a cell-permeable peptidomimetic, shepherdin, modeled on the binding interface between the molecular chaperone Hsp90 and the antiapoptotic and mitotic regulator, survivin. Shepherdin makes extensive contacts with the ATIP pocket of Hsp90, destabilizes its client proteins, and induces massive death of tumor cells by apoptotic and nonapoptotic mechanisms. Conversely, shepherdin does not reduce the viability of normal cells, and does not affect colony formation of purified hematopoietic progenitors. Systemic administration of shepherdin in vivo is well tolerated, and inhibits human tumor growth in mice without toxicity. Shepherdin could provide a potent and selective anticancer agent in humans. (literal)

Titolo

• Rational design of shepherdin, a novel anticancer agent (literal)

Abstract

• Anticancer agents that selectively kill tumor cells and spare normal tissues are urgently needed. Here, we engineered a cell-permeable peptidomimetic, shepherdin, modeled on the binding interface between the molecular chaperone Hsp90 and the antiapoptotic and mitotic regulator, survivin. Shepherdin makes extensive contacts with the ATIP pocket of Hsp90, destabilizes its client proteins, and induces massive death of tumor cells by apoptotic and nonapoptotic mechanisms. Conversely, shepherdin does not reduce the viability of normal cells, and does not affect colony formation of purified hematopoietic progenitors. Systemic administration of shepherdin in vivo is well tolerated, and inhibits human tumor growth in mice without toxicity. Shepherdin could provide a potent and selective anticancer agent in humans. (literal)

Prodotto di

• Targeting e inibizione dell'angiogenesi per la terapia anti-cancro (PM.P01.007.003) (Modulo)
• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)

Autore CNR

• GIORGIO COLOMBO (Unità di personale interno)
• MASSIMILIANO MELI (Unità di personale esterno)

Incoming links:

Prodotto

• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)
• Targeting e inibizione dell'angiogenesi per la terapia anti-cancro (PM.P01.007.003) (Modulo)

Autore CNR di

• GIORGIO COLOMBO (Unità di personale interno)
• MASSIMILIANO MELI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cancer cell (Rivista)