Decrease in pathology and progression of scrapie after immunisation with synthetic prion protein peptides in hamsters (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Decrease in pathology and progression of scrapie after immunisation with synthetic prion protein peptides in hamsters (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Alternative label

• Magri G., Clerici M., Dall'Ara P., Biasin M., Caramelli M., Casalone C., Giannino M.L., Longhi R., Piacentini L., Della Bella S., Gazzuola P., Martino P.A., Della Bella S., Pollera C., Puricelli M., Servida F., Crescio I., Boasso A., Ponti W., Poli G. (2005)
  Decrease in pathology and progression of scrapie after immunisation with synthetic prion protein peptides in hamsters
  in Vaccine
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Magri G., Clerici M., Dall'Ara P., Biasin M., Caramelli M., Casalone C., Giannino M.L., Longhi R., Piacentini L., Della Bella S., Gazzuola P., Martino P.A., Della Bella S., Pollera C., Puricelli M., Servida F., Crescio I., Boasso A., Ponti W., Poli G. (literal)

Pagina inizio

• 2862 (literal)

Pagina fine

• 2868 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 23 (literal)

Rivista

• Vaccine (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Decrease in pathology and progression of scrapie after immunisation with synthetic prion protein peptides in hamsters (literal)

Abstract

• Effective therapy for prion diseases is currently unavailable. Recently, vaccination was shown to be effective in mouse models of a particular neurodegenerative conditions: Alzheimer's disease (AD). Here, we report that vaccination with synthetic oligopeptides homologous to the hamster (Mesocricetus auratus) prion protein augments survival time in animals infected intraperitoneally with 263K scrapie agent. For each hamster included in the study, prion-specific serum antibodies as well as deposition of pathological prion protein (PrPres), glial fibrillary acidic protein (GFAP), and mRNA expression for cytokines (TNF alpha, IL-1 beta, IL-10) in brain tissues were evaluated. In immunized animals, increased survival after challenge was associated with a reduction of cerebral lesion, PrP deposition and GFAP expression; in these animals, anti-prion protein peptide antibody levels were increased, and the expression of pro-inflammatory cytokines (TNF alpha and IL-1 beta) was reduced. Vaccination could be an effective therapeutic approach to postpone disease onset. (c) 2004 Elsevier Ltd. All rights reserved. (literal)

Prodotto di

• Modellistica molecolare di proteine legate a processi patologici (PM.P01.026.002) (Modulo)
• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)

Autore CNR

• RENATO LONGHI (Unità di personale interno)

Incoming links:

Autore CNR di

• RENATO LONGHI (Unità di personale interno)

Prodotto

• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)
• Modellistica molecolare di proteine legate a processi patologici (PM.P01.026.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Vaccine (Rivista)