http://www.cnr.it/ontology/cnr/individuo/prodotto/ID17365
A beta(31-35) peptide induce apoptosis in PC 12 cells: Contrast with A beta(25-35) peptide and examination of underlying mechanisms (Articolo in rivista)
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- A beta(31-35) peptide induce apoptosis in PC 12 cells: Contrast with A beta(25-35) peptide and examination of underlying mechanisms (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Alternative label
Misiti F., Sampaolese B., Pezzotti M., Marini S., Coletta M., Ceccarelli L., Giardina B., Clementi M.E. (2005)
A beta(31-35) peptide induce apoptosis in PC 12 cells: Contrast with A beta(25-35) peptide and examination of underlying mechanisms
in Neurochemistry international
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- Misiti F., Sampaolese B., Pezzotti M., Marini S., Coletta M., Ceccarelli L., Giardina B., Clementi M.E. (literal)
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- ISI Web of Science (WOS) (literal)
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- Misiti F: Institute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, Facoltà di Medicina e Chirurgia, Largo F. Vito 1-00168 Rome, Italy
Sampaolese B: CNR Istituto di Chimica del Riconoscimento Molecolare (ICRM), Largo F. Vito 1-00168 Rome, Italy
Pezzotti M: Institute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, Facoltà di Medicina e Chirurgia, Largo F. Vito 1-00168 Rome, Italy
Marini S: Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata, 135-00133 Rome, Italy
Coletta M: Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via di Tor Vergata, 135-00133 Rome, Italy
Ceccarelli L: Institute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, Facoltà di Medicina e Chirurgia
Giardina B: CNR Istituto di Chimica del Riconoscimento Molecolare (ICRM) and Institute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, Facoltà di Medicina e Chirurgia
Clementi M.E.: CNR Istituto di Chimica del Riconoscimento Molecolare (ICRM) c/o Institute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, Facoltà di Medicina e Chirurgia (literal)
- Titolo
- A beta(31-35) peptide induce apoptosis in PC 12 cells: Contrast with A beta(25-35) peptide and examination of underlying mechanisms (literal)
- Abstract
- The toxic behaviour of the two shorter sequences of the native A² amyloid peptide required for cytotoxicity i.e., A²(31-35) and A²(2535) peptides, was studied. We have shown that A²(31-35) peptide induces neurotoxicity in undifferentiated PC 12 cell via an apoptotic cell death pathway, including caspase activation and DNA fragmentation. A²(25-35) peptide, like the shorter amyloid peptide has the ability to induce neurotoxicity, as evaluated by the MTS reduction assay and by adherent cell count, but the A²(25-35) peptide-induced neurotoxicity is not associated with any biochemical features of apoptosis. The differences observed between the neurotoxic properties of A²(31-35) and A²(25-35) peptides might result on their different ability to be internalised within the neuronal cells. Furthermore, this study reveals that the redox state of methionine residue, C-terminal in A²(31-35) and A²(25-35) peptides affect in a different way the toxic behaviour of these two short amyloid fragments. Taken together our results suggest that A²(31-35) peptide induces cell death by apoptosis, unlike the A²(25-35) peptide and that role played by methionine-35 in A² induced neurotoxicity might be related to the A² aggregation state. (literal)
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