Novel cationic solid-lipid nanoparticles as non-viral vectors for gene delivery (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Novel cationic solid-lipid nanoparticles as non-viral vectors for gene delivery (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Bondì ML, Azzolina A, Craparo EF, Lampiasi N, Capuano G, Giammona G, Cervello M. (2007)
  Novel cationic solid-lipid nanoparticles as non-viral vectors for gene delivery
  in Journal of drug targeting (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bondì ML, Azzolina A, Craparo EF, Lampiasi N, Capuano G, Giammona G, Cervello M. (literal)

Pagina inizio

• 295 (literal)

Pagina fine

• 301 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 15 (literal)

Rivista

• Journal of drug targeting (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Bondi ML ISMN, CNR Lampiasi Nadia, Azzolina Antonina, Cervello Melchiorre IBIM CNR (literal)

Titolo

• Novel cationic solid-lipid nanoparticles as non-viral vectors for gene delivery (literal)

Abstract

• In this paper, the suitability of novel cationic solid-lipid nanoparticles (SLN) as a nonviral transfection agent for gene delivery was investigated. SLN were produced by using the microemulsion method and Compritol ATO 888 as matrix lipid, dimethyldioctadecylammonium bromide as charge carrier and Pluronic F68 as surfactant. Obtained nanoparticles were approximately 120nm in size and positively charged, with a zeta potential value equal to þ45mV in twice-distilled water. Cationic SLN were able to form stable complexes with DNA and to protect DNA against DNase I digestion. The SLN-DNA complexes were characterized by mean diameter and zeta potential measurements. In vitro studies on human liver cancer cells demonstrated a very low degree of toxicity of both SLN and SLN-DNA complexes. Further, SLN-DNA complexes were able to promote transfection of liver cancer cells. These data suggest that our cationic SLN may be potentially useful for gene therapy. (literal)

Prodotto di

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Segnali cellulari critici nella biologia della cellula neoplastica (SV.P15.005.001) (Modulo)
• Sintesi e crescita di film e superfici nanostrutturate (PM.P05.004.002) (Modulo)
• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)

Autore CNR

• NADIA LAMPIASI (Unità di personale interno)
• MARIA LUISA BONDI' (Unità di personale interno)
• MELCHIORRE CERVELLO (Persona)
• ANTONINA AZZOLINA (Persona)

Incoming links:

Autore CNR di

• MELCHIORRE CERVELLO (Persona)
• NADIA LAMPIASI (Unità di personale interno)
• ANTONINA AZZOLINA (Persona)
• MARIA LUISA BONDI' (Unità di personale interno)

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)
• Sintesi e crescita di film e superfici nanostrutturate (PM.P05.004.002) (Modulo)
• Segnali cellulari critici nella biologia della cellula neoplastica (SV.P15.005.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of drug targeting (Rivista)