Nanostructured lipid carriers-containing anticancer compounds: preparation, characterization, and cytotoxicity studies (Articolo in rivista)

Type
Label
  • Nanostructured lipid carriers-containing anticancer compounds: preparation, characterization, and cytotoxicity studies (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1080/10717540600739914 (literal)
Alternative label
  • Bondì ML, Craparo EF, Giammona G, Cervello M, Azzolina A, Diana P, Martorana A, Cirrincione G. (2007)
    Nanostructured lipid carriers-containing anticancer compounds: preparation, characterization, and cytotoxicity studies
    in Drug delivery; Librapharm/Informa Healthcare, London (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bondì ML, Craparo EF, Giammona G, Cervello M, Azzolina A, Diana P, Martorana A, Cirrincione G. (literal)
Pagina inizio
  • 61 (literal)
Pagina fine
  • 67 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 14 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • ISMN-CNR DIPARTIMENTO DI CHIMICA E TECNOLOGIE FARMACEUTICHE-UNIPA IBIM-CNR DIPARTIMENTO FARMACOCHIMICO (literal)
Titolo
  • Nanostructured lipid carriers-containing anticancer compounds: preparation, characterization, and cytotoxicity studies (literal)
Abstract
  • This article describes the development of nanostructured lipid carriers (NLC) as colloidal carriers for two antitumor compounds that possess a remarkable antineoplastic activity. But their limited stability and lowsolubility in water could give a very lowparenteral bioavailability. Results revealed an enhancement of the cytotoxicity effect of drug-loaded NLC on human prostate cancer (PC-3) and human hepatocellular carcinoma (HuH-6, HuH-7) cell lines with respect to that of both free drugs. Results of characterization studies strongly support the potential application of these drugs-loaded NLC as prolonged delivery systems for lipophilic drugs by several administration routes, in particular for intravenous administration. (literal)
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