http://www.cnr.it/ontology/cnr/individuo/prodotto/ID173005

The intracellular effects of non-ionic amphiphilic cyclodextrin nanoparticles in the delivery of anticancer drugs (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

The intracellular effects of non-ionic amphiphilic cyclodextrin nanoparticles in the delivery of anticancer drugs (Articolo in rivista) (literal)

Anno

2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1016/j.biomaterials.2008.09.035 (literal)

Alternative label

Fabiana Quaglia; Luisanna Ostacolo; Antonino Mazzaglia; Valentina Villari; Daniela Zaccaria; Maria T. Sciortino (2009)
The intracellular effects of non-ionic amphiphilic cyclodextrin nanoparticles in the delivery of anticancer drugs
in Biomaterials; Elsevier Science Ltd., Oxford (Regno Unito)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Fabiana Quaglia; Luisanna Ostacolo; Antonino Mazzaglia; Valentina Villari; Daniela Zaccaria; Maria T. Sciortino (literal)

Pagina inizio

374 (literal)

Pagina fine

382 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

30 (literal)

Rivista

Biomaterials (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

3 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Dipartimento di Chimica Farmaceutica e Tossicologica, University of Napoli Federico II, Via Domenico Montesano 49, 80131 Napoli, Italy Istituto per lo Studio dei Materiali Nanostrutturati, Consiglio Nazionale delle Ricerche, ISMN-CNR, c/o Dipartimento di Chimica Inorganica, Chimica Fisica e Chimica Analitica, Universita` di Messina, Salita Sperone 31, 98166 Messina, Italy Istituto per i Processi Chimico Fisici, Consiglio Nazionale delle Ricerche, IPCF-CNR, Salita Sperone, Contrada Papardo, 98158, Faro Superiore, Messina, Italy Dipartimento di Scienze della Vita, Sezione di Microbiologia, Genetica e Biologia Molecolare, Universita` di Messina, Salita Sperone 31, 98166 Messina, Italy (literal)

Titolo

The intracellular effects of non-ionic amphiphilic cyclodextrin nanoparticles in the delivery of anticancer drugs (literal)

Abstract

The aim of this study was to develop nanoparticles made of the amphiphilic cyclodextrin heptakis (2-O-oligo(ethyleneoxide)-6-hexadecylthio-)-beta-CD (SC160H) entrapping docetaxel (Doc) and establish their in vivo potential. Doc-loaded SC160H nanoparticles were prepared by the emulsion-solvent evaporation technique and fully characterized for size, zeta potential, amount of entrapped drug, release rate and degradation rate. Spherical vesicular nanoparticles displaying a hydrodynamic radius of about 95 nm which did not change upon storage as an aqueous dispersion, a negative zeta potential and entrapment efficiency of Doc very close to 100\% were produced. DSC study highlighted the crystalline nature of SC160H, unloaded and Doc-loaded SC160H nanoparticles which resulted in their very slow dissolution during release stage and well-modulated release of entrapped Doc for about 8 weeks. Doc-loaded SC160H nanoparticles were not hemolytic toward red blood cells as compared to a commercial Doc formulation (Taxotere (R)) which shows a dose-dependent toxicity. After exposure of HEp-2 cells to equivalent doses of free Doc and Doc-loaded SC160H nanoparticles, superior cell killing and cell damage were observed for nanoparticles. Finally, cell damage was attributed to aberrant mitosis which was found to be significantly higher for HEp-2 cells treated with Doc-loaded SC160H nanoparticles as compared to free Doc likely due to the ability of nanoparticles to slowly release the drug allowing prolonged cell arrest in mitosis. Taken together, these results highlights a great potential of nanoparticles based on SC160H in solid tumors therapy. (literal)

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