Stem cell recruitment and liver de-differentiation in MMTV-neu (ErbB-2) transgenic mice. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Stem cell recruitment and liver de-differentiation in MMTV-neu (ErbB-2) transgenic mice. (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Freitas I, Fracchiolla S, Baronzio G, Griffini P, Bertone R, Sitar GM, Barni S, Gerzeli G, Sacco MG. (2003)
  Stem cell recruitment and liver de-differentiation in MMTV-neu (ErbB-2) transgenic mice.
  in Anticancer research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Freitas I, Fracchiolla S, Baronzio G, Griffini P, Bertone R, Sitar GM, Barni S, Gerzeli G, Sacco MG. (literal)

Pagina inizio

• 3783 (literal)

Pagina fine

• 3794 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 23 (literal)

Rivista

• Anticancer research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Ricercatori afferenti al CNR/ Ricercatori associati: I. Freitas; S. Barni - Impact Factor: 1.347 (literal)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Stem cell recruitment and liver de-differentiation in MMTV-neu (ErbB-2) transgenic mice. (literal)

Abstract

• The liver of tumor-bearing hosts manifests fetal phenotypes. We investigated the expression of differentiation markers on the liver in MMTV-neu (ErbB-2) transgenic mice, in the period from incipient neoangiogenesis to lung metastatization. We report AFP expression by hepatocytes in all lobular zones, CD34 cell arrest and subsequent hemopoiesis in periportal and mid-zone areas, oval-like cells (CD34+, CK19+, AFP+) and ductular reaction in portal tracts, portal CK19+ and GGT+ hepatoblast-like cells, and midzonal large dysplastic hepatocytes. We hypothesize that CD34 cells are recruited by the tumor from the marrow for angiogenic purposes and that their differentiation in the liver is influenced by altered liver microenvironment(s). AFP may act as a growth factor and biological response modifier for these cells and for the tumor. Dysplasia might be enhanced by metabolic stress. We conclude that the liver differentiation potential is lobular-zone-dependent and that the risk for eventually developing a pre-malignant lesion is not negligible. (literal)

Prodotto di

• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• MARIA GRAZIA SACCO (Unità di personale interno)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)

Autore CNR di

• MARIA GRAZIA SACCO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Anticancer research (Rivista)