http://www.cnr.it/ontology/cnr/individuo/prodotto/ID172365
Visceral fat and beta cell function in non diabetic humans (Articolo in rivista)
- Type
- Label
- Visceral fat and beta cell function in non diabetic humans (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1007/s00125-005-1891-3 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Gastaldelli A.; Sironi A.M.; Ciociaro D.; Positano V.; Buzzigoli E.; Giannessi D.; Lombardi M.; Mari A.; Ferrannini E. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
- Times Cited: 19 (from Web of Science) 2013 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.ncbi.nlm.nih.gov/pubmed/16086140 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- In: \"Diabetologia\"48,2005,10,2090-2096 (literal)
- Note
- ISI Web of Science (WOS) (literal)
- ubMe (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1,3,4,5,6: IFC-CNR Pisa;
8: ISIB-CNR
7: Metabolism Unit, Department of Internal Medicine and Consiglio Nazionale delle
Richerche Institute of Clinical Physiology (literal)
- Titolo
- Visceral fat and beta cell function in non diabetic humans (literal)
- Abstract
- AIMS/HYPOTHESIS:
Preferential visceral adipose tissue (VAT) accumulation has been clearly associated with insulin resistance. In contrast, the impact of visceral obesity on beta cell function is controversial.
METHODS:
In 62 non-diabetic women and men (age 24-69 years, BMI 21-39 kg/m2), we measured VAT and subcutaneous adipose tissue (SAT) fat mass by magnetic resonance imaging. We also measured insulin secretion and beta cell function by C-peptide deconvolution and physiological modelling of data from a frequently sampled, 75-g, 3-h OGTT, respectively.
RESULTS:
VAT (range 0.1-3.1 kg) was strongly related to sex, age and BMI; SAT was related to sex and BMI. Controlling for sex, age, BMI and SAT by multivariate analysis, excess VAT was associated with a clinical phenotype comprising higher plasma glucose levels, BP, heart rate and serum transaminases. The corresponding metabolic phenotype consisted of insulin resistance (partial r=-0.38) and hyperinsulinaemia (partial r=0.29). The latter, however, was appropriate for the degree of insulin resistance regardless of obesity and abdominal fat distribution. Moreover, none of the model-derived parameters describing beta cell function (glucose sensitivity, rate sensitivity and potentiation) was independently associated with excess VAT.
CONCLUSIONS/INTERPRETATION:
In non-diabetic Caucasian adults of either sex, preferential visceral fat deposition in itself is part of an insulin-resistant phenotype. The insulin secretory response to a physiological challenge is increased to fully compensate for the insulin resistance, but the dynamics of beta cell function (glucose sensitivity, rate sensitivity and potentiation) are largely preserved. (literal)
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- Autore CNR
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