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Time-resolved diffuse optical spectroscopy of small tissue samples (Articolo in rivista)

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Time-resolved diffuse optical spectroscopy of small tissue samples (Articolo in rivista) (literal)

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Taroni, P; Comelli, D; Farina, A; Pifferi, A; Kienle, A (2007)
Time-resolved diffuse optical spectroscopy of small tissue samples
in Optics express
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Politecn Milan, CNR, INFM, ULTRAS,Dipartimento Fis, I-20133 Milan, Italy; Politecn Milan, CNR, IFN, I-20133 Milan, Italy; Inst Lasertechnol Med & Messtech, D-89081 Ulm, Germany (literal)

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Time-resolved transmittance spectroscopy was performed in the wavelength range of 610 or 700 to 1050 nm on phantom parallelepipeds and bone tissue cubes of different sizes. The data were best fitted with solutions of the diffusion equation for a laterally infinite slab and for a parallelepiped to investigate how size and optical properties of the samples affect the results obtained with the two models. Monte Carlo simulations were also performed to support and help with the interpretation of the experimental data. The parallelepiped model performs much better than the infinite slab model for the estimate of the reduced scattering coefficient and, even more, the absorption coefficient. It can profitably be used to quantify the optical properties of biological tissue samples and to derive information such as tissue composition, when small volumes are involved. (c) 2007 Optical Society of America. (literal)

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