Microelectronic photosensors for genetic diagnostic microsystems (Articolo in rivista)

Type
Label
  • Microelectronic photosensors for genetic diagnostic microsystems (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Alternative label
  • Rech I., Restelli A.; Cova S.; Ghioni M.; Chiari M.; Cretich M. (2004)
    Microelectronic photosensors for genetic diagnostic microsystems
    in Sensors and actuators. B, Chemical (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Rech I., Restelli A.; Cova S.; Ghioni M.; Chiari M.; Cretich M. (literal)
Pagina inizio
  • 158 (literal)
Pagina fine
  • 162 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 100 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Politecnico di Milano-DEI, piazza Leonardo da Vinci 32, 20133 Milan, Italy CNR-ICRM, via M. Bianco, 20133 Milan, Italy (literal)
Titolo
  • Microelectronic photosensors for genetic diagnostic microsystems (literal)
Abstract
  • Techniques for DNA and protein analysis and separation rely on laser-induced fluorescence (LIF) and employ ultra-sensitive photo-sensors (photo-multiplier tubes or PMT's, etc.) that are bulky and costly. A key issue for compact and economical instruments is the availability of miniaturized and economical ultra-sensitive sensors. The planar silicon single-photon avalanche diodes (SPAD's) join typical microelectronic advantages (miniaturization, ruggedness, low voltage, power, and cost) to sensitivity comparable to PMT's. A compact system is described with a dual SPAD-based LIF detection system and a glass microchip for capillary electrophoresis (CE). Sensitivity better than 3 pM with injection volume 50 pl is achieved in the separation of CY5 DNA labelled fragments. (literal)
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