http://www.cnr.it/ontology/cnr/individuo/prodotto/ID171447
Ru(III)-based compounds with sulfur donor ligands: synthesis, characterization, electrochemical behaviour and anticancer activity (Articolo in rivista)
- Type
- Label
- Ru(III)-based compounds with sulfur donor ligands: synthesis, characterization, electrochemical behaviour and anticancer activity (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1039/b806341a (literal)
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Lorena Giovagnini; Sergio Sitran; Ignazio Castagliuolo; Paola Brun; Maddalena Corsini; Piero Zanello; Alfonso Zoleo; Annalisa Maniero; Barbara Biondi; Dolores Fregona (2008)
Ru(III)-based compounds with sulfur donor ligands: synthesis, characterization, electrochemical behaviour and anticancer activity
in Dalton transactions (2003. Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Lorena Giovagnini; Sergio Sitran; Ignazio Castagliuolo; Paola Brun; Maddalena Corsini; Piero Zanello; Alfonso Zoleo; Annalisa Maniero; Barbara Biondi; Dolores Fregona (literal)
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- Department of Chemical Sciences, University of Padova;
Institute of Inorganic and Surfaces Chemistry,C.N.R., Padova;
Department of Histology,Microbiology and MedicalBiotechnology, Section of Microbiology and Virology, University of Padova;
Department of Chemistry, University of Siena; (literal)
- Titolo
- Ru(III)-based compounds with sulfur donor ligands: synthesis, characterization, electrochemical behaviour and anticancer activity (literal)
- Abstract
- In recent years, Ru(III) complexes have emerged as a new class of effective anticancer agents against tumors that proved to be resistant to all other chemotherapeutic drugs currently in clinical use. To extend our previous studies on metal complexes containing sulfur-donor ligands, we report here on the synthesis and characterization, by means of several spectroscopic and analytical techniques, some [Ru(RSDT)3] and [Ru2(RSDT)5]Cl complexes with dithiocarbamato ligands derived from methyl/ethyl/tert-butyl esters of sarcosine. Their electrochemical behaviour was also studied by cyclic voltammetry. All the complexes were tested for their cytotoxicity on a panel of human tumor cell lines showing highly significant antitumor activity. The chemical and biological properties of the newly synthesized complexes, were compared with those of [Ru(DMDT)3] and [Ru2(DMDT)5]Cl species (DMDT = N,N-dimethyldithiocarbamate) whose chemical (not biological) characterization has been already reported in literature. (literal)
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