Statistical assessment of functional categories of genes deregulated in pathological conditions by using microarray data (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Statistical assessment of functional categories of genes deregulated in pathological conditions by using microarray data (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Maglietta R., Piepoli A., Catalano D., Licciulli F., Carella M., Liuni S., Pesole G., Perri F. and Ancona N. (2007)
  Statistical assessment of functional categories of genes deregulated in pathological conditions by using microarray data
  in Bioinformatics (Oxf., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Maglietta R., Piepoli A., Catalano D., Licciulli F., Carella M., Liuni S., Pesole G., Perri F. and Ancona N. (literal)

Pagina inizio

• 2063 (literal)

Pagina fine

• 2072 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 23 (literal)

Rivista

• Bioinformatics (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Istituto di Studi sui Sistemi Intelligenti per l'A;utomazione, CNR, Via Amendola 122/D-I, 70126 Bari, 2 Unità Operativa di Gastroenterologia, IRCCS, ‘Casa Sollievo della Sofferenza’-Ospedale, Viale Cappuccini, 71013 San Giovanni Rotondo (FG), 3 Istituto di Tecnologie Biomediche-Sezione di Bari, CNR, Via Amendola 122/D, 70126 Bari, 4 Servizio di Genetica Medica, IRCCS, ‘Casa Sollievo della Sofferenza’-Ospedale, Viale Cappuccini, 71013 San Giovanni Rotondo (FG) and 5 Dipartimento di Biochimica e Biologia Molecolare - Università di Bari, Via E. Orabona 4, 70126 Bari, Italy (literal)

Titolo

• Statistical assessment of functional categories of genes deregulated in pathological conditions by using microarray data (literal)

Abstract

• Motivation: A major challenge in current biomedical research is the identification of cellular processes deregulated in a given pathology through the analysis of gene expression profiles. To this end, predefined lists of genes, coding specific functions, are compared with a list of genes ordered according to their values of differential expression measured by suitable univariate statistics. Results: We propose a statistically well-founded method for measuring the relevance of predefined lists of genes and for assessing their statistical significance starting from their raw expression levels as recorded on the microarray. We use prediction accuracy as a measure of relevance of the list. The rationale is that a functional category, coded through a list of genes, is perturbed in a given pathology if it is possible to correctly predict the occurrence of the disease in new subjects on the basis of the expression levels of the genes belonging to the list only. The accuracy is estimated with multiple random validation strategy and its statistical significance is assessed against a couple of null hypothesis, by using two independent permutation tests. The utility of the proposed methodology is illustrated by analyzing the relevance of Gene Ontology terms belonging to biological process category in colon and prostate cancer, by using three different microarray data sets and by comparing it with current approaches. (literal)

Prodotto di

• Institute of intelligent systems for automation (ISSIA) (Istituto)
• Sistemi Sensoriali per il Controllo di Qualità e Diagnostica (SP.P03.002.001) (Modulo)
• Bioinformatica per la Genomica Funzionale e Comparata (SV.P18.004.001) (Modulo)

Autore CNR

• NICOLA ANCONA (Unità di personale interno)
• ROSALIA MAGLIETTA (Unità di personale esterno)
• GRAZIANO PESOLE (Persona)
• SABINO LIUNI (Persona)
• VITO FLAVIO LICCIULLI (Unità di personale interno)

Incoming links:

Prodotto

• Institute of intelligent systems for automation (ISSIA) (Istituto)
• Bioinformatica per la Genomica Funzionale e Comparata (SV.P18.004.001) (Modulo)
• Sistemi Sensoriali per il Controllo di Qualità e Diagnostica (SP.P03.002.001) (Modulo)

Autore CNR di

• VITO FLAVIO LICCIULLI (Unità di personale interno)
• NICOLA ANCONA (Unità di personale interno)
• SABINO LIUNI (Persona)
• GRAZIANO PESOLE (Persona)
• ROSALIA MAGLIETTA (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Bioinformatics (Rivista)