http://www.cnr.it/ontology/cnr/individuo/prodotto/ID171095
Cardiac catheterization and long-term chromosomal damage in children with congenital heart disease (Articolo in rivista)
- Type
- Label
- Cardiac catheterization and long-term chromosomal damage in children with congenital heart disease (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1093/eurheartj/ehl014 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Maria Grazia Andreassi; Lamia Ait-Ali; Nicoletta Botto; Samantha Manfredi;
Gaetano Mottola; Eugenio Picano; (literal)
- Pagina inizio
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- In: European Heart Journal, vol. 27 (22) pp. 2703-2708. Oxford Journals, 2006. (literal)
- Note
- PubMe (literal)
- ISI Web of Science (WOS) (literal)
- Scopu (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- CNR-IFC , Institute of Clinical Physiology, Pisa, Italy;
Scuola Superiore S. Anna, Pisa, Italy;
Clinica Cardiologica MonteVergine, Mercogliano, Avellino, Italy (literal)
- Titolo
- Cardiac catheterization and long-term chromosomal damage in children with congenital heart disease (literal)
- Abstract
- Aims Medical radiological exposure is associated with an additional risk of cancer. Children with
repaired congenital heart disease (CHD) are theoretically at a relatively greater cancer risk as the
radiological exposure can be intensive in these patients. Chromosomal aberrations test (CA) and
micronucleus assay (MN) in peripheral blood lymphocytes are biomarkers of chromosomal damage and
intermediate endpoints in carcinogenesis.
Methods and results The frequency of CA and MN was assessed in three groups of patients: Group I, 32
exposed patients (17 males, age ¼ 15.5+8.3 years) who underwent cardiac procedures employing
ionizing radiation (mostly cardiac catheterization) for CHD between 1965 and 2000; Group II, 32
healthy age- and sex-matched subjects (17 males, age ¼ 14.1+12.3 years), and Group III, 10
newborn non-exposed patients (7 males) with CHD. Exposed patients of Group I had a mean value of
2.9+1.4 cardiac catheterization (range 1-5) procedures per person. The mean frequency of CA was
higher in the exposed patients (Group I ¼ 2.8+1.9% vs. Group II ¼ 0.7+0.7%; vs. Group
III ¼ 0.8+0.8%; P , 0.0001). Similarly, the mean values of MN were higher in the exposed patients
(Group I ¼12.3+5.1? vs. Group II ¼ 6.0+3.8?; vs. Group III ¼ 4.4+1.4?; P , 0.0001).
Conclusion Cardiac ionizing procedures are associated with a long-lasting mark in the chromosomal
damage of exposed children with CHD. (literal)
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