RISC activity in hippocampus is essential for contextual memory (Articolo in rivista)

Type
Label
  • RISC activity in hippocampus is essential for contextual memory (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.neulet.2010.01.038 (literal)
Alternative label
  • Batassa EM, Costanzi M, Saraulli D, Scardigli R, Barbato C, Cogoni C, Cestari V. (2010)
    RISC activity in hippocampus is essential for contextual memory
    in Neuroscience letters (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Batassa EM, Costanzi M, Saraulli D, Scardigli R, Barbato C, Cogoni C, Cestari V. (literal)
Pagina inizio
  • 185 (literal)
Pagina fine
  • 188 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Epub 2010 Jan 28 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.sciencedirect.com/science/article/pii/S0304394010000765 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 471 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 4 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 3 (literal)
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a) Dep. of Cellular Biotechnology, and Ematology, University of Rome “La Sapienza”, Italy; b) European Brain Research Institute, Rome, Italy; c) CNR, Neuroscience Institute, Rome, Italy; d) Faculty of Educational Science, LUMSA University, Rome, Italy; e) INMM - Istituto di Neurobiologia e Medicina Molecolare, CNR, Rome, Italy. - (literal)
Titolo
  • RISC activity in hippocampus is essential for contextual memory (literal)
Abstract
  • RNA-Induced Silencing Complex (RISC) mediates post-transcriptional control of gene expression and contains Argonaute 2 (AGO2) protein as a central effector of cleavage or inhibition of mRNA translation. In the brain, the RISC pathway is involved in neuronal functions, such as synaptic development and local protein synthesis, which are potentially critical for memory. In this study, we examined the role of RISC in memory formation in rodents, by silencing AGO2 expression in dorsal hippocampus of C57BL/6 mice and submitting animals to hippocampus-related tasks. One week after surgery, AGO2 downregulation impaired both short-term and long-term contextual fear memories. Conversely, no long-lasting effects were observed three weeks after surgery, when AGO2 levels were re-established. These results show that altered RISC activity severely affects learning and memory processes in rodents. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it