http://www.cnr.it/ontology/cnr/individuo/prodotto/ID171063
RISC activity in hippocampus is essential for contextual memory (Articolo in rivista)
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- RISC activity in hippocampus is essential for contextual memory (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.neulet.2010.01.038 (literal)
- Alternative label
Batassa EM, Costanzi M, Saraulli D, Scardigli R, Barbato C, Cogoni C, Cestari V. (2010)
RISC activity in hippocampus is essential for contextual memory
in Neuroscience letters (Print)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Batassa EM, Costanzi M, Saraulli D, Scardigli R, Barbato C, Cogoni C, Cestari V. (literal)
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- Epub 2010 Jan 28 (literal)
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- http://www.sciencedirect.com/science/article/pii/S0304394010000765 (literal)
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- a) Dep. of Cellular Biotechnology, and Ematology, University of Rome La Sapienza, Italy;
b) European Brain Research Institute, Rome, Italy;
c) CNR, Neuroscience Institute, Rome, Italy;
d) Faculty of Educational Science, LUMSA University, Rome, Italy;
e) INMM - Istituto di Neurobiologia e Medicina Molecolare, CNR, Rome, Italy. - (literal)
- Titolo
- RISC activity in hippocampus is essential for contextual memory (literal)
- Abstract
- RNA-Induced Silencing Complex (RISC) mediates post-transcriptional control of gene expression and contains Argonaute 2 (AGO2) protein as a central effector of cleavage or inhibition of mRNA translation. In the brain, the RISC pathway is involved in neuronal functions, such as synaptic development and local protein synthesis, which are potentially critical for memory. In this study, we examined the role of RISC in memory formation in rodents, by silencing AGO2 expression in dorsal hippocampus of C57BL/6 mice and submitting animals to hippocampus-related tasks. One week after surgery, AGO2 downregulation impaired both short-term and long-term contextual fear memories. Conversely, no long-lasting effects were observed three weeks after surgery, when AGO2 levels were re-established. These results show that altered RISC activity severely affects learning and memory processes in rodents. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. (literal)
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