Role of the amino sugar in the DNA binding of disaccharide anthracyclines: crystal structure of the complex MAR70/d(CGATCG). (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Role of the amino sugar in the DNA binding of disaccharide anthracyclines: crystal structure of the complex MAR70/d(CGATCG). (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bmc.2004.12.007 (literal)

Alternative label

• Temperini C., Cirilli M., Aschi M., Ughetto G. (2005)
  Role of the amino sugar in the DNA binding of disaccharide anthracyclines: crystal structure of the complex MAR70/d(CGATCG).
  in Bioorganic & medicinal chemistry (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Temperini C., Cirilli M., Aschi M., Ughetto G. (literal)

Pagina inizio

• 1673 (literal)

Pagina fine

• 1679 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 13 (literal)

Rivista

• Bioorganic & medicinal chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a Department of Chemistry, University of Florence, 50019 Sesto F.no (FI), Italy; b Institute of Neurobiology and Molecular Medicine, Rome, Italy; c Department of Chemistry, Chemical Engineering and Materials, University of l’Aquila, 67010 l’Aquila, Italy; d Institute of Crystallography, CNR, cp 10, 00016 Monterotondo Stazione, Italy; Temperini C. Department of Chemistry, University of Florence Cirilli M. -IC-CNR, Roma Aschi M. -Department of Chemistry, Chemical Engineering and Materials, University of l’Aquila Ughetto G. IC-CNR, Roma (literal)

Titolo

• Role of the amino sugar in the DNA binding of disaccharide anthracyclines: crystal structure of the complex MAR70/d(CGATCG). (literal)

Abstract

• Disaccharide anthracyclines analogues have been shown to exhibit different antitumour activity as compared with parents compounds doxorubicin and daunomycin. Here we report the crystal structure of the disaccharide analog MAR70 complexed with the DNA hexamer d(CGATCG). The structure has been solved at 1.54A resolution and is similar to previous crystallized anthracycline-DNA complexes with both sugar rings of the disaccharide chain lying in the DNA minor groove. Comparison with the structure of MEN10755 another disaccharide anthracycline co-crystallized with the same DNA hexamer suggests a correlation between the position of the amino sugar on the disaccharide chain and the conformation of this moiety when binding to DNA. This is discussed with respect to the influence on drug activity and on the possible interaction with other cellular targets. (literal)

Prodotto di

• Meccanismi oncogenici dell'apoptosi quali targets per lo sviluppo dinuove sostanze ad azione farmacologica (ME.P03.011.001) (Modulo)
• Institute of Crystallography (IC) (Istituto)
• Studi strutturali e funzionali di acidi nucleici (PM.P06.001.002) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• GIOVANNI UGHETTO (Persona)
• MAURIZIO CIRILLI (Persona)

Incoming links:

Prodotto

• Institute of Crystallography (IC) (Istituto)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Studi strutturali e funzionali di acidi nucleici (PM.P06.001.002) (Modulo)
• Meccanismi oncogenici dell'apoptosi quali targets per lo sviluppo dinuove sostanze ad azione farmacologica (ME.P03.011.001) (Modulo)

Autore CNR di

• MAURIZIO CIRILLI (Persona)
• GIOVANNI UGHETTO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Bioorganic & medicinal chemistry (Rivista)