CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1 (Articolo in rivista)

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  • CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1 (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/onc.2010.179 (literal)
Alternative label
  • Leone V, Mansueto G, Pierantoni GM, Tornincasa M, Merolla F, Cerrato A, Santoro M, Grieco M, Scaloni A, Celetti A, Fusco A. (2010)
    CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1
    in Oncogene (Basingstoke); Palgrave Macmillan Ltd., Basingstoke (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Leone V, Mansueto G, Pierantoni GM, Tornincasa M, Merolla F, Cerrato A, Santoro M, Grieco M, Scaloni A, Celetti A, Fusco A. (literal)
Pagina inizio
  • 4341 (literal)
Pagina fine
  • 4351 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.nature.com/onc/journal/v29/n30/full/onc2010179a.html (literal)
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  • 29 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • 2010 Jul 29;29(30):4341-51. Epub 2010 May 24. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 11 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 30 (literal)
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  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Univ Naples Federico 2, Dipartimento Biol & Patol Cellulare & Mol, Ist Endocrinol & Oncol Sperimentale, Fac Med & Chirurg Napoli,CNR, I-80131 Naples, Italy Biotechnol Avanzate Napoli, NOGEC, CEINGE, Naples, Italy European Sch Mol Med, SEMM, Naples, Italy CNR, Prote & Mass Spectrometry Lab, ISPAAM, Naples, Italy (literal)
Titolo
  • CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1 (literal)
Abstract
  • RET/papillary thyroid carcinoma 1 (PTC1) oncogene is frequently activated in human PTCs. It is characterized by the fusion of the intracellular kinase-encoding domain of RET to the first 101 amino acids of CCDC6. The aim of our work is to characterize the function of the CCDC6 protein to better understand the function of its truncation, that results in the loss of the expression of one allele, in the process of thyroid carcinogenesis. Here, we report that CCDC6 interacts with CREB1 and represses its transcriptional activity by recruiting histone deacetylase 1 and protein phosphatase 1 proteins at the CRE site of the CREB1 target genes. Finally, we show an increased CREB1 phosphorylation and activity in PTCs carrying the RET/PTC1 oncogene. Consistently, an increased expression of two known CREB1 target genes, AREG and cyclin A, was observed in this subgroup of thyroid papillary carcinomas. Therefore, the repression of CREB1 activity by CCDC6 has a critical function in the development of human thyroid papillary carcinomas carrying RET/PTC1 activation. (literal)
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