Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells. (Articolo in rivista)

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Label
  • Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.imlet.2007.02.004 (literal)
Alternative label
  • Malfitano AM, Toruner GA, Gazzerro P, Laezza C, Husain S, Eletto D, Orlando P, De Petrocellis L, Terskiy A, Schwalb M, Vitale E, Bifulco M. (2007)
    Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells.
    in Immunology letters; ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, AMSTERDAM (Paesi Bassi)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Malfitano AM, Toruner GA, Gazzerro P, Laezza C, Husain S, Eletto D, Orlando P, De Petrocellis L, Terskiy A, Schwalb M, Vitale E, Bifulco M. (literal)
Pagina inizio
  • 145 (literal)
Pagina fine
  • 154 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 109 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Univ Salerno, Dipartimento Sci Farmaceut, Fisciano, SA, Italy 2. Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Microbiol & Mol Genet, Newark, NJ 07103 USA 3. Univ Naples Federico II, CNR, Ist Endocrinol & Oncol Sperimentale, Naples, Italy 4. Univ Naples Federico II, Dipartimento Biol & Patol Cellulare & Mol, Naples, Italy 5. CNR, Ist Biochim Prot & Enzimol, Pozzuoli, Na, Italy 6. CNR, Ist Cibernet, Pozzuoli, Na, Italy (literal)
Titolo
  • Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells. (literal)
Abstract
  • In this study we analysed the regulation of gene expression by arvanil and anandamide in human peripheral blood mononuclear cells (PBMCs) to clarify their immunosuppressive properties. PBMCs were activated, leading to CD36 down regulation, that was normalized by arvanil and anandamide. We used microarray technology to identify a regulatory pattern associated with cell proliferation in the presence of both substances. CD3-CD28 stimulated PBMCs showed a pattern of up-regulated and down-regulated genes after treatment with these substances. We selected and analysed several genes chosen by their function in the regulation of cell proliferation. We showed a transcriptional control of the CD36 gene by arvanil and anandamide associated with an increased protein expression, thus suggesting a possible role of CD36 in anandamide and arvanil anti-inflammatory pattern. (literal)
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