http://www.cnr.it/ontology/cnr/individuo/prodotto/ID170930

Elucidation of real-time hardening mechanisms of two novel high-strength calcium phosphate bone cements (Articolo in rivista)

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Elucidation of real-time hardening mechanisms of two novel high-strength calcium phosphate bone cements (Articolo in rivista) (literal)

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Alternative label

Smirnov V.V., Rau J.V., Generosi A., Rossi Albertini V., Ferro D., Barinov S.M. (2010)
Elucidation of real-time hardening mechanisms of two novel high-strength calcium phosphate bone cements
in Journal of biomedical materials research. Part B, Applied biomaterials; John Wiley & Sons Inc., Hoboken (Stati Uniti d'America)
(literal)

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Smirnov V.V., Rau J.V., Generosi A., Rossi Albertini V., Ferro D., Barinov S.M. (literal)

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Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow 119991, Russia Istituto di Struttura della Materia, CNR, Via del Fosso del Cavaliere, 100-00133 Rome, Italy Istituto per lo Studio dei Materiali Nanostrutturati, CNR, Piazzale Aldo Moro, 5-00185 Rome, Italy (literal)

Titolo

Elucidation of real-time hardening mechanisms of two novel high-strength calcium phosphate bone cements (literal)

Abstract

Despite the numerous literature data available in the field of calcium phosphate bone cements, the mechanism and kinetics of their hardening, both of which are of great importance for cements application, in most cases, is unknown. In this work, the mechanism and kinetics of hardening of two novel high-strength calcium phosphate bone cements were studied using the energy dispersive X-ray diffraction technique, which allows rapid collection of the patterns. The phase transformations occurring on the setting and hardening processes were monitored in situ. Containing minimal quantity of components, whose mixing leads to the formation of cements with pH close to neutral, the cements under study are simple in handling. The main component of both formulations is tetracalcium phosphate. In both cements, the effect of the addition of high- and low-molecular weight chitosan on phase development and kinetics was investigated in detail. One of the cements has the compressive strength of about 70 MPa, whereas the strength of the other, containing Ca3Al2O6, is much higher, about 100 MPa. This latter cement could be regarded as an alternative to the common low-strength bioresorbable brushite cements. (literal)

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