Chronic activation of ERK and neurodegenerative diseases. (Articolo in rivista)

Type
Label
  • Chronic activation of ERK and neurodegenerative diseases. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Colucci-D'Amato L. 1, Perrone-Capano C. 2, di Porzio U. 3 (2003)
    Chronic activation of ERK and neurodegenerative diseases.
    in BioEssays
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Colucci-D'Amato L. 1, Perrone-Capano C. 2, di Porzio U. 3 (literal)
Pagina inizio
  • 1085 (literal)
Pagina fine
  • 1095 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Impact Factor = 8,314 Interdisciplinarietà del prodotto: The Authors belong to different scientific areas, sectors and Istitutions. IMPACT FACTOR 8,314 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 25 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • The extracellular-signal regulated kinases 1/2 (ERK or ERKs) are involved in the regulation of important neuronal functions, including neuronal plasticity in normal and pathological conditions. We present findings that support the notion that the kinetics and localization of ERK are intrinsically linked, in that the duration of ERK activation dictates its subcellular compartmentalization and/or trafficking. The latter, in turn, dictates whether ERK-expressing cells would enter a program of cell death, survival or differentiation. We summarize experimental data showing that chronic activation of ERK plays a role in the mechanisms that trigger neurodegeneration. We also discuss how MKPs, members of the subclass of dual specificity phosphatases, might be the link between ERK kinetics and its subcellular localization. Il lavoro affre un'escurso dello stato dell'arte della regolazione della fosforilazione mediante MAPK e della segnalazione intracellulare e dimostra che attivazione cronica di ERK (MAPKKK) è implicata nella neurodegenerazione. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 IEOS, CNR, Naples, Italy; 2 University of Catanzaro Magna Grecia, Faculty of Pharmacy, Roccelletta di Borgia (CZ), Italy; 3 Institute of Genetics and Biophysics, Adriano Buzzati Traverso, CNR, Naples, Italy (literal)
Titolo
  • Chronic activation of ERK and neurodegenerative diseases. (literal)
Abstract
  • The extracellular-signal regulated kinases 1/2 (ERK or ERKs) are involved in the regulation of important neuronal functions, including neuronal plasticity in normal and pathological conditions. We present findings that support the notion that the kinetics and localization of ERK are intrinsically linked, in that the duration of ERK activation dictates its subcellular compartmentalization and/or trafficking. The latter, in turn, dictates whether ERK-expressing cells would enter a program of cell death, survival or differentiation. We summarize experimental data showing that chronic activation of ERK plays a role in the mechanisms that trigger neurodegeneration. We also discuss how MKPs, members of the subclass of dual specificity phosphatases, might be the link between ERK kinetics and its subcellular localization. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it