http://www.cnr.it/ontology/cnr/individuo/prodotto/ID170771
'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease. (Articolo in rivista)
- Type
- Label
- 'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease. (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Mastroberardino P.G., Iannicola C., Nardacci R., Bernassola F., De Laurenzi V., Melino G., Moreno S., Pavone F., Oliverio S., Fesus L., Piacentini M. (2002)
'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease.
in Cell death and differentiation
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Mastroberardino P.G., Iannicola C., Nardacci R., Bernassola F., De Laurenzi V., Melino G., Moreno S., Pavone F., Oliverio S., Fesus L., Piacentini M. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Titolo
- 'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease. (literal)
- Abstract
- By crossing Huntington's disease (HD) R6/1 transgenic mice with
'tissue' transglutaminase (TG2) knock-out mice, we have
demonstrated that this multifunctional enzyme plays an important
role in the neuronal death characterising this disorder in vivo. In fact,
a large reduction in cell death is observed in R6/1, TG2(-/-) compared
with R6/1 transgenic mice. In addition, we have shown that the
formation of neuronal intranuclear inclusions (NII) is potentiated in
absence of the 'tissue' transglutaminase. These phenomena are
paralleled by a significant improvement both in motor performances
and survival of R6/1, TG2(-/-) versus R6/1 mice. Taken together
these findings suggest an important role for tissue
transglutaminase in the regulation of neuronal cell death occurring in
Huntington's disease. (literal)
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