http://www.cnr.it/ontology/cnr/individuo/prodotto/ID170690
TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications (Articolo in rivista)
- Type
- Label
- TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Starowicz K.; Cristino L.; Di Marzo V. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Luigia Cristino= Endocannabinoid Research Group, Istituto di Cibernetica \"Edoardo Caianiello\", C.N.R., Pozzuoli (Naples), Italy
Katarzyna Starowicz, Vincenzo Di Marzo= Endocannabinoid Research Group, Istituto di Chimica Biololecolare, C.N.R., Pozzuoli (Naples), Italy (literal)
- Titolo
- TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications (literal)
- Abstract
- Increasing evidence exists to support the presence of functional transient receptor potential vanilloid type 1 (TRPV1) channels
in the brain, where these receptors are unlikely to be activated by high temperature and low pH. Here we review this evidence as well as
the literature data pointing to the potential role of endovanilloid-activated brain TRPV1 channels not only in the supraspinal control of
pain, body temperature, cardiovascular and respiratory functions and emesis, but also in anxiety and locomotion. This literature provides
the first bases for the possible future development of new therapeutic approaches that, by specifically targeting brain TRPV1 receptors,
might be used for the treatment of pain as well as affective and motor disorders. (literal)
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