TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications (Articolo in rivista)

Type
Label
  • TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Starowicz K.; Cristino L.; Di Marzo V. (2008)
    TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications
    in Current pharmaceutical design (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Starowicz K.; Cristino L.; Di Marzo V. (literal)
Pagina inizio
  • 42 (literal)
Pagina fine
  • 54 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 14 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Luigia Cristino= Endocannabinoid Research Group, Istituto di Cibernetica \"Edoardo Caianiello\", C.N.R., Pozzuoli (Naples), Italy Katarzyna Starowicz, Vincenzo Di Marzo= Endocannabinoid Research Group, Istituto di Chimica Biololecolare, C.N.R., Pozzuoli (Naples), Italy (literal)
Titolo
  • TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications (literal)
Abstract
  • Increasing evidence exists to support the presence of functional transient receptor potential vanilloid type 1 (TRPV1) channels in the brain, where these receptors are unlikely to be activated by high temperature and low pH. Here we review this evidence as well as the literature data pointing to the potential role of endovanilloid-activated brain TRPV1 channels not only in the supraspinal control of pain, body temperature, cardiovascular and respiratory functions and emesis, but also in anxiety and locomotion. This literature provides the first bases for the possible future development of new therapeutic approaches that, by specifically targeting brain TRPV1 receptors, might be used for the treatment of pain as well as affective and motor disorders. (literal)
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