Effects of increasing doses of glucagon-like peptide-1 on insulin-releasing phases during intravenous glucose administration in mice (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Effects of increasing doses of glucagon-like peptide-1 on insulin-releasing phases during intravenous glucose administration in mice (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1152/ajpregu.00687.2010 (literal)

Alternative label

• Chan, H.M.;Jain, R.;Ahrén, B.;Pacini, G.;D'Argenio, D.Z., (2011)
  Effects of increasing doses of glucagon-like peptide-1 on insulin-releasing phases during intravenous glucose administration in mice
  in American journal of physiology. Regulatory, integrative and comparative physiology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Chan, H.M.;Jain, R.;Ahrén, B.;Pacini, G.;D'Argenio, D.Z., (literal)

Pagina inizio

• R1126 (literal)

Pagina fine

• R1133 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/21307364 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 300 (literal)

Rivista

• American journal of physiology. Regulatory, integrative and comparative physiology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1, 2, 5: Department of Biomedical Engineering, University of Southern California, Los Angeles, California; 3: Department of Clinical Sciences, Lund University, Lund, Sweden; 4: Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padua, Italy (literal)

Titolo

• Effects of increasing doses of glucagon-like peptide-1 on insulin-releasing phases during intravenous glucose administration in mice (literal)

Abstract

• Chan HM, Jain R, Ahren B, Pacini G, D'Argenio DZ. Effects of increasing doses of glucagon-like peptide-1 on insulin-releasing phases during intravenous glucose administration in mice. Am J Physiol Regul Integr Comp Physiol 300: R1126-R1133, 2011. First published February 9, 2010; doi:10.1152/ajpregu.00687.2010.-The increase in insulin secretion caused by glucagon-like peptide-1 (GLP-1) and GLP-1 mimetics observed during an intravenous glucose test (IVGTT) has been reported in both normal and disease animal models, as well as in humans. In this study, a hierarchical population modeling approach is used, together with a previously reported model relating glucose to insulin appearance, to determine quantitative in vivo dose-response relationships between GLP-1 dose level and both first-and second-phase insulin release. Parameters of the insulin kinetic model were estimated from the complete set of glucose and insulin data collected in 219 anesthetized nonfasted NMR-imaged mice after intravenous injection of glucose (1 g/kg) alone or with GLP-1 (0.03-100 nmol/kg). The resulting dose-response curves indicate a difference in GLP-1 effect on the two release phases, as is also evident from the different ED(50) parameter values (0.107 vs. 6.65 nmol/kg for phase 1 vs. phase 2 insulin release parameters). The first phase of insulin release is gradually augmented with increasing GLP-1 dose, reaching saturation at a dose of similar to 1 nmol/kg, while the second-phase release changes more abruptly at GLP-1 doses between 3 and 10 nmol/kg and shows a more pronounced 100-fold increase between control and the high GLP-1 dose of 100 nmol/kg Moreover, separate disposition indices calculated for phase 1 and 2 insulin release, show a different pattern of increase with increasing GLP-1 dose. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Institute of biomedical engineering (ISIB) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR

• GIOVANNI PACINI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Effects of increasing doses of glucagon-like peptide-1 on insulin-releasing phases during intravenous glucose administration in mice" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di neuroscienze (IN) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR di

• GIOVANNI PACINI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• American journal of physiology. Regulatory, integrative and comparative physiology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Effects of increasing doses of glucagon-like peptide-1 on insulin-releasing phases during intravenous glucose administration in mice" (Insieme di parole chiave)