http://www.cnr.it/ontology/cnr/individuo/prodotto/ID170555
Influence of myocardial fibrosis and blood oxygenation on heart T2* values in thalassemia patients (Articolo in rivista)
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- Label
- Influence of myocardial fibrosis and blood oxygenation on heart T2* values in thalassemia patients (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/jmri.21704 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Meloni A.; Pepe A.; Positano V.; Favilli B.; Maggio A.; Capra M.; Lo Pinto C.; Gerardi C.; Santarelli M. F.; Midiri M.; Landini L.; Lombardi M. (literal)
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- http://www.scopus.com/inward/record.url?eid=2-s2.0-65249183906&partnerID=40&md5=28ebad095f51d069f7d1d157a62b48de (literal)
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- In: Journal of Magnetic Resonance Imaging, vol. 29 (4) pp. 832 - 837. Wiley Periodicals, Inc, 2009. In: Journal of Magnetic Resonance Imaging, vol. 29 (4) pp. 832 - 837. Wiley, 2009. (literal)
- Note
- ISI Web of Science (WOS) (literal)
- Scopus (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- CNR-IFC, Pisa, Fondazione G. Monasterio Pisa, 2Ematologia II con Talassemia, \"V. Cervello\" Hospital, Palermo (Italy), Pediatria per le Emopatie Ereditarie, \"G. Di Cristina\" Hospital ARNAS, Palermo (Italy), Pediatria II per le Emopatie Ereditarie, Villa Sofia-CTO Hospital, Palermo (Italy), Centro Talassemia Ospedali Civili Riuniti, Sciacca (Agrigento, Italy), Department of Radiology, University of Palermo, Palermo (Italy), Department of Information Engineering, University of Pisa, Pisa (Italy) (literal)
- Titolo
- Influence of myocardial fibrosis and blood oxygenation on heart T2* values in thalassemia patients (literal)
- Abstract
- Purpose: To determine whether T2* measurements quantifying myocardial iron overload in thalassemia patients are influenced by myocardial fibrosis and blood oxygenation. Materials and Methods: Multislice multiecho T2* was performed in 94 thalassemia patients in order to quantify myocardial iron overload. The left ventricle was automatically segmented into a 16-segment standardized heart model, and the T2* value on each segment as well as the global T2* were calculated. Delayed enhanced cardiovascular magnetic resonance (DE-CMR) images were obtained to detect myocardial fibrosis. The blood oxygenation was assessed by the noninvasive measurement of partial pressure of oxygen(pO2). Results: Myocardial fibrosis was detected in 31 patients (33%). The global T2* value in patients with fibrosis was comparable with that of patients without fibrosis (P = 0.88) and T2* values in segments with fibrosis were comparable with those in segments without fibrosis (P = 0.83). The global T2* value was not correlated with the pO2 (Spearman's coefficient of correlation = 0.99). Conclusion: Myocardial fibrosis and blood oxygenation did not significantly affect the T2* values. These data further support the use of heart T2* as equivalent of heart iron in the clinical arena. (literal)
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