http://www.cnr.it/ontology/cnr/individuo/prodotto/ID170553
Amphiphilic Cyclodextrins as capping agents for gold colloids: a spectroscopic investigation with perspectives in photothermal therapy (Articolo in rivista)
- Type
- Label
- Amphiphilic Cyclodextrins as capping agents for gold colloids: a spectroscopic investigation with perspectives in photothermal therapy (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1021/jp7120033 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Antonino Mazzaglia; Mariachiara Trapani; Valentina Villari; Norberto Micali; Francesca Marino Merlo; Daniela Zaccaria; Maria Teresa Sciortino; Francesco Previti; Salvatore Patane; Luigi Monsu Scolaro (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto per lo Studio dei Materiali Nanostrutturati, ISMN-CNR Messina, Salita Sperone 31, 98166 Messina, Italy,
Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica, UniVersita` di Messina, and
CIRCMSB, Salita Sperone 31, 98166 Messina, Italy,
Istituto per i Processi Chimico Fisici, IPCF-CNR, Salita Sperone, Contrada Papardo, 98158, Faro Superiore, Messina, Italy,
Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, UniVersita` di Messina, Salita Sperone 31, 98166 Messina, Italy,
Dipartimento di Fisica della Materia e Tecnologie Fisiche AVanzate, UniVersita` di Messina, Contrada di Dio, S. Agata, 98166, Messina, Italy (literal)
- Titolo
- Amphiphilic Cyclodextrins as capping agents for gold colloids: a spectroscopic investigation with perspectives in photothermal therapy (literal)
- Abstract
- Amphiphilic cyclodextrins (CDs) modified in the upper rim with thiohexyl groups and in the lower rim with
oligoethylene amino (SC6NH2) or oligoethylene hydroxyl groups (SC6OH) can bind gold colloids, yielding
Au/CD particles with an average hydrodynamic radius (RH) of 2 and 25 nm in water solution. The systems
were investigated by UV-vis, quasi-elastic light scattering, and FTIR-ATR techniques. The concentration of
amphiphiles was kept above the concentration of gold colloids to afford complete covering. In the case of
SC6NH2, basic conditions (Et3N, pH 11) yield promptly the decoration of Au, which can be stabilized by
linkage of CD amino and/or thioether groups. The critical aggregation concentration of SC6NH2 was measured
(?4 íM) by surface tension measurements, pointing out that about 50% of CDs are present in nonaggregated
form. Whereas Au/SC6NH2 colloids were stable in size and morphology for at least one month, the size of
the Au/SC6OH system increases remarkably, forming nanoaggregates of 20 and 80 nm in two hours. Under
physiological conditions, the gold/amino amphiphiles system can internalize in HeLa cells, as shown by
extinction spectra registered on the immobilized cells. The gold delivered by cyclodextrins can induce
photothermal damage upon irradiation, doubling the cell mortality with respect to uncovered gold colloids.
These findings can open useful perspectives to the application of these self-assembled systems in cancer
photothermal therapy. (literal)
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