A truncated form of teratocarcinoma-derived growth factor-1 (cripto-1) mRNA expressed in human colon carcinoma cell lines and tumors. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• A truncated form of teratocarcinoma-derived growth factor-1 (cripto-1) mRNA expressed in human colon carcinoma cell lines and tumors. (Articolo in rivista) (literal)

Anno

• 2001-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1159/000050629 (literal)

Alternative label

• Baldassarre G, Tucci M, Lembo G, Pacifico FM, Dono R, Lago CT, Barra A, Bianco C, Viglietto G, Salomon D, Persico MG. (2001)
  A truncated form of teratocarcinoma-derived growth factor-1 (cripto-1) mRNA expressed in human colon carcinoma cell lines and tumors.
  in Tumor biology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Baldassarre G, Tucci M, Lembo G, Pacifico FM, Dono R, Lago CT, Barra A, Bianco C, Viglietto G, Salomon D, Persico MG. (literal)

Pagina inizio

• 286 (literal)

Pagina fine

• 293 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 22 (literal)

Rivista

• Tumor biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopus (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• International Institute of Genetics and Biophysics, CNR, Naples, Italy; Istituto per lo Studio e la Cura dei Tumori, 'Fondazione Pascale', Naples, Italy; Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, MD, United States (literal)

Titolo

• A truncated form of teratocarcinoma-derived growth factor-1 (cripto-1) mRNA expressed in human colon carcinoma cell lines and tumors. (literal)

Abstract

• The human teratocarcinoma-derived growth factor (TDGF)-1 gene encodes a 188-amino acid protein, cripto-1. The TDGF-1 gene is overexpressed in the majority of human primary colorectal carcinomas and hepatic metastases, in breast carcinomas and in testicular nonseminoma germ cell embryonal carcinomas. In the human embryonal carcinoma cell line NTERA-2 clone D1, a 2-kb TDGF-1 mRNA transcript is expressed. The present study shows that a 1.7-kb mRNA transcript lacking the first two exons of the TDGF-1 gene is expressed in the human colon carcinoma cell line GEO. This shorter mRNA is the only TDGF-1 transcript that is present in the majority of primary human colorectal carcinomas and hepatic metastases and in adult human tissues such as the pancreas, heart, stomach, mammary gland, skeletal muscle, liver and placenta. In contrast, in the kidney, brain, testis, ovary and spleen, the longer 2-kb TDGF-1 mRNA transcript is expressed. The putative shorter protein starts at a CUG codon 129 nucleotides downstream of the starting AUG codon of the longer protein. These data indicate the potential for differential transcriptional regulation of the TDGF-1 gene in different normal and tumor tissues. (literal)

Prodotto di

• Meccanismi di controllo dell'apoptosi e sviluppo di terapie antineoplastiche innovative (SV.P15.012.002) (Modulo)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)

Autore CNR

• MARIA PERSICO (Persona)
• CARMINE TEODORO LAGO (Unità di personale interno)
• GIUSEPPE VIGLIETTO (Persona)
• FRANCESCO MARIA PACIFICO (Persona)

Incoming links:

Autore CNR di

• FRANCESCO MARIA PACIFICO (Persona)
• GIUSEPPE VIGLIETTO (Persona)
• CARMINE TEODORO LAGO (Unità di personale interno)
• MARIA PERSICO (Persona)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Meccanismi di controllo dell'apoptosi e sviluppo di terapie antineoplastiche innovative (SV.P15.012.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Tumor biology (Rivista)