Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.2337/db07-1315 (literal)

Alternative label

• Muscelli E.; Mari A.; Casolaro A.; Camastra S.; Seghieri G.; Gastaldelli A.; Holst J.; Ferrannini E. (2008)
  Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients
  in Diabetes (N.Y.N.Y.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Muscelli E.; Mari A.; Casolaro A.; Camastra S.; Seghieri G.; Gastaldelli A.; Holst J.; Ferrannini E. (literal)

Pagina inizio

• 1340 (literal)

Pagina fine

• 1348 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/18162504 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 57 (literal)

Rivista

• Diabetes (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• In: Diabetes, vol. 57 (5) pp. 1340 - 1348. American Diabetes Association, 2008. (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1, 3, 4, 5, 6, 8: Department of Internal Medicine and Consiglio Nazionale delle Ricerche (CNR) Institute of Clinical Physiology, University of Pisa, Italy; 2: CNR Institute of Biomedical Engineering, Padova, Italy; 5: Division of Internal Medicine, Spedali Riuniti, Pistoia, Italy; 7: Department of Medical Physiology, Panum Institute, Copenhagen, Denmark. (literal)

Titolo

• Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients (literal)

Abstract

• OBJECTIVE: To quantitate the separate impact of obesity and hyperglycemia on the incretin effect (i.e., the gain in beta-cell function after oral glucose versus intravenous glucose). RESEARCH DESIGN AND METHODS: Isoglycemic oral (75 g) and intravenous glucose administration was performed in 51 subjects (24 with normal glucose tolerance [NGT], 17 with impaired glucose tolerance [IGT], and 10 with type 2 diabetes) with a wide range of BMI (20-61 kg/m(2)). C-peptide deconvolution was used to reconstruct insulin secretion rates, and beta-cell glucose sensitivity (slope of the insulin secretion/glucose concentration dose-response curve) was determined by mathematical modeling. The incretin effect was defined as the oral-to-intravenous ratio of responses. In 8 subjects with NGT and 10 with diabetes, oral glucose appearance was measured by the double-tracer technique. RESULTS: The incretin effect on total insulin secretion and beta-cell glucose sensitivity and the GLP-1 response to oral glucose were significantly reduced in diabetes compared with NGT or IGT (P or (literal)

Prodotto di

• MEDICINA TRASLAZIONALE (ME.P05.016.001) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)
• Institute of biomedical engineering (ISIB) (Istituto)

Autore CNR

• ANDREA MARI (Unità di personale interno)
• eleuterio ferrannini (Unità di personale esterno)
• AMALIA GASTALDELLI (Persona)

Insieme di parole chiave

• Parole chiave di "Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di fisiologia clinica (IFC) (Istituto)
• MEDICINA TRASLAZIONALE (ME.P05.016.001) (Modulo)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR di

• AMALIA GASTALDELLI (Persona)
• ANDREA MARI (Unità di personale interno)
• eleuterio ferrannini (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Diabetes (Rivista)

Insieme di parole chiave di

• Parole chiave di "Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients" (Insieme di parole chiave)