Catanionic Systems from Conversion of Nucleotides into Nucleo-Lipids (Articolo in rivista)

Type
Label
  • Catanionic Systems from Conversion of Nucleotides into Nucleo-Lipids (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/la702580j (literal)
Alternative label
  • Angelico R., Ceglie A., Cuomo F., Cardellicchio C., Mascolo G., Colafemmina G. (2008)
    Catanionic Systems from Conversion of Nucleotides into Nucleo-Lipids
    in Langmuir
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Angelico R., Ceglie A., Cuomo F., Cardellicchio C., Mascolo G., Colafemmina G. (literal)
Pagina inizio
  • 2348 (literal)
Pagina fine
  • 2355 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 24 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Consorzio per lo sViluppo dei Sistemi a Grande Interfase (CSGI) c/o UniVersita` del Molise (DISTAAM), V. De Sanctis, I-86100 Campobasso, Italy, CNR (ICCOM), Dipartimento di Chimica, UniVersita` di Bari, Via Orabona 4, I-70126 Bari, Italy, CNR (IRSA), Via F. De Blasio 5, I-70123 Bari, Italy, and Dipartimento di Chimica, UniVersita` di Bari, V. Orabona 4, I-70126 Bari, Italy (literal)
Titolo
  • Catanionic Systems from Conversion of Nucleotides into Nucleo-Lipids (literal)
Abstract
  • This article focuses on reactions performed in nanostructured environments where the pair of complementary nucleotides, 5¢-AMP and 5¢-UMP, are converted into their amphiphilic derivatives. The synthesis is carried out by using the hydrophobic reactant dodecyl epoxide (DE) dispersed in a micellar solution based on the cationic surfactant cetyltrimethylammoniumbromide (CTAB). Novel nucleo-lipids monomers and CTAB molecules give rise to the spontaneous self-assembly of catanionic supramolecular structures in water, showing typical Maltese crosses in optical microscopy. In the final colloidal suspensions, mono- and dichained derivatives have been identified in the system incubated with 5¢-UMP through LC-QqTOF-MS analysis, whereas only mono-alkylated adducts are found in the analogue reaction with 5¢-AMP. A new di-alkylated 5¢-UMP adduct is obtained from the 1:1 mixture of both complementary nucleotides, in addition to the nucleo-lipids found in separate systems. Time-resolvedDLSmeasurements reveal very different kinetic processes for aggregates' formation when 5¢-UMP, 5¢-AMP, or their equimolar combination are used in the reaction mixture. This system as a whole represents a potential experimental model where the effect of both intermolecular interactions and self-association processes can be investigated by tuning the type of nucleobases in the reaction mixtures. (literal)
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