The contribution of oxidative stress in apoptosis of human-cultured astroglial cells induced by supernatants of HIV-1-infected macrophages. (Articolo in rivista)

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  • The contribution of oxidative stress in apoptosis of human-cultured astroglial cells induced by supernatants of HIV-1-infected macrophages. (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Mollace V., Salvemini D., Riley Dp., Muscoli C., Iannone M., Granato T., Masuelli L., Modesti A., Rotiroti D., Nistico R., Bertoli A., Perno Cf., Aquaro S. (2002)
    The contribution of oxidative stress in apoptosis of human-cultured astroglial cells induced by supernatants of HIV-1-infected macrophages.
    in Journal of leukocyte biology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mollace V., Salvemini D., Riley Dp., Muscoli C., Iannone M., Granato T., Masuelli L., Modesti A., Rotiroti D., Nistico R., Bertoli A., Perno Cf., Aquaro S. (literal)
Pagina inizio
  • 65 (literal)
Pagina fine
  • 72 (literal)
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  • 71 (literal)
Rivista
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  • progetto di ricerca n. 65 Rotiroti D. รจ associato all'Istituto (literal)
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  • Our results support the role of oxidative stress mediated by HIV-1-infected M/M as one of the leading causes of neurodegeneration in patients with HIV-1 and suggest the use of nonpeptidic SOD mimetics to counteract HIV-1-related neurological disorders. (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • 1, University of Catanzaro, Faculty of Pharmacy; 2, Metaphore Pharmaceutics, St. Louis, USA; 3, CNR, Institute of Neurological Sciences, Section of Pharmacology; 4, University of Calabria, Faculty of Pharmacy, Arcavacata di Rende, (CS); (literal)
Titolo
  • The contribution of oxidative stress in apoptosis of human-cultured astroglial cells induced by supernatants of HIV-1-infected macrophages. (literal)
Abstract
  • Apoptosis of neurons and astrocytes has been found in patients undergoing AIDS dementia complex. We demonstrated that supernatants from human primary macrophages (M/M) infected by HIV-1 lead human astroglial cells to oxidative stress, as shown by elevated levels of malondialdehyde, and then to apoptosis. Electron microscopy of astrocytes shortly incubated with HIV-1-infected M/M supernatants showed apoptotic blebbing, cytoplasmic loss, and chromatin condensation. Apoptosis was antagonized by pretreating astrocytes with the nonpeptidic superoxide dismutase (SOD) mimetic M40401 but not with anti-HIV-1 compounds, thus showing that apoptosis of astrocytes driven by HIV-1-infected M/M supernatants is mainly mediated by abnormal production of superoxide anions without relationship to HIV-1 replication in such cells. Overall results support the role of oxidative stress mediated by HIV-1-infected M/M as one of the leading causes of neurodegeneration in patients with HIV-1 and suggest the use of nonpeptidic SOD mimetics to counteract HIV-1-related neurological disorders. (literal)
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