Modulation of the immune response by probiotic strains in a mouse model of gluten sensitivity (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Modulation of the immune response by probiotic strains in a mouse model of gluten sensitivity (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Alternative label

• D'arienzo R.; Maurano F.; Lavermicocca P.; Ricca E.; Rossi M. (2009)
  Modulation of the immune response by probiotic strains in a mouse model of gluten sensitivity
  in Cytokine (Phila. Pa., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• D'arienzo R.; Maurano F.; Lavermicocca P.; Ricca E.; Rossi M. (literal)

Pagina inizio

• 254 (literal)

Pagina fine

• 259 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 48 (literal)

Rivista

• Cytokine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Food Sciences, CNR, Avellino, Italy Institute of Sciences of Food Production, CNR, Bari, Italy Department of Structural and Functional Biology, University Federico II, Naples, Italy (literal)

Titolo

• Modulation of the immune response by probiotic strains in a mouse model of gluten sensitivity (literal)

Abstract

• Probiotic strains play an important role in modulating activities in the gut-associated lymphoid tissue. Elucidation of the mechanisms that mediate probiotic-driven immunomodulation may facilitate their therapeutic application for specific immune-mediated diseases or for prophylaxis. In this study, we explored the effect of different Lactobacillus spp. and Bifidobacterium lactis in transgenic mice expressing the human DQ8 heterodimer, a HLA molecule linked to Celiac Disease (CD). In vitro analysis on immature bone marrow-derived dendritic cells (iBMDCs) showed that all strains up-regulated surface B7-2 (CD86), indicative of DC maturation, however, with different intensity. No strain induced appreciable levels of IL-10 or IL-12 in iBMDCs, whereas TNF-alpha expression was essentially elicited by Lactobacillus paracasei and Lactobacillus fermentum. Interestingly, these strains were found also to increase the antigen-specific TNF-alpha secretion in vivo, following co-administration of probiotic bacteria in mice mucosally immunized with the gluten component gliadin. Together these findings highlighted the ability of probiotics to exert strain-specific inductive rather than suppressive effects both on the innate and adaptive immunity in a mouse model of food antigen sensitivity. (literal)

Prodotto di

• Istituto di scienze delle produzioni alimentari (ISPA) (Istituto)
• Microbiologia e qualità delle produzioni alimentari (AG.P05.016.001) (Modulo)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)
• Institute of food sciences (ISA) (Istituto)

Autore CNR

• PAOLA LAVERMICOCCA (Persona)
• Rossana D'Arienzo (Persona)
• MAURO ROSSI (Unità di personale interno)
• FRANCESCO MAURANO (Persona)

Incoming links:

Prodotto

• Institute of food sciences (ISA) (Istituto)
• Istituto di scienze delle produzioni alimentari (ISPA) (Istituto)
• Microbiologia e qualità delle produzioni alimentari (AG.P05.016.001) (Modulo)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)

Autore CNR di

• MAURO ROSSI (Unità di personale interno)
• PAOLA LAVERMICOCCA (Persona)
• FRANCESCO MAURANO (Persona)
• Rossana D'Arienzo (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cytokine (Rivista)