Identification of Inhibitors of Drug-Resistant Candida albicans Strains from a Library of Bicyclic Peptidomimetic Compounds (Articolo in rivista)

Type
Label
  • Identification of Inhibitors of Drug-Resistant Candida albicans Strains from a Library of Bicyclic Peptidomimetic Compounds (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/jm901734u (literal)
Alternative label
  • Trabocchi Andrea; Mannino Claudia; Machetti Fabrizio; De Bernardis Flavia; Arancia Silvia; Cauda Roberto; Cassone Antonio; Guarna Antonio (2010)
    Identification of Inhibitors of Drug-Resistant Candida albicans Strains from a Library of Bicyclic Peptidomimetic Compounds
    in Journal of medicinal chemistry; ACS, American chemical society, Washington, DC (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Trabocchi Andrea; Mannino Claudia; Machetti Fabrizio; De Bernardis Flavia; Arancia Silvia; Cauda Roberto; Cassone Antonio; Guarna Antonio (literal)
Pagina inizio
  • 2502 (literal)
Pagina fine
  • 2509 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 53 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
  • Scopus (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto Superiore di Sanita Dipartimento di Chimica U. Schiff dell' Università di Firenze Istituto di Chimica dei Composti Organo metallici del CNR Università Cattolica Sacro Cuore (literal)
Titolo
  • Identification of Inhibitors of Drug-Resistant Candida albicans Strains from a Library of Bicyclic Peptidomimetic Compounds (literal)
Abstract
  • The screening of a library of small molecule peptidomimetics toward secreted aspartic proteinase-2 (SAP2) of Candida aibicans allowed us to identify two compounds that showed in vitro inhibitory potency comparable to pepstatin A. In an experimental model of vaginal candidiasis, the two candidate compounds were as active as a therapeutic dose of fluconazole. Importantly, this activity was fully preserved when the challenger was a fluconazole-resistant strain of the fungus. Altogether, our data demonstrate SAP2 as a valid C. albicans target for the development of new drugs against this important human pathogen. (literal)
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