Multislice multiecho T2* cardiac magnetic resonance for the detection of heterogeneous myocardial iron distribution in thalassaemia patients (Articolo in rivista)

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  • Multislice multiecho T2* cardiac magnetic resonance for the detection of heterogeneous myocardial iron distribution in thalassaemia patients (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/nbm.1382 (literal)
Alternative label
  • Positano, V (Positano, Vincenzo)[ 1,2 ] ; Pepe, A (Pepe, Alessia)[ 1,2 ] ; Santarelli, MF (Santarelli, Maria Filomena)[ 1,2 ] ; Ramazzotti, A (Ramazzotti, Anna)[ 1,2 ] ; Meloni, A (Meloni, Antonella)[ 1,2 ] ; De Marchi, D (De Marchi, Danielle)[ 1,2 ] ; Favilli, B (Favilli, Brunella)[ 1,2 ] ; Cracolici, E (Cracolici, Eliana)[ 3 ] ; Midiri, M (Midiri, Massimo)[ 3 ] ; Spasiano, A (Spasiano, Anna)[ 4 ] ; Lombardi, M (Lombardi, Massimo)[ 1,2 ] ; Landini, L (Landini, Luigi)[ 1,2,5 ] (2009)
    Multislice multiecho T2* cardiac magnetic resonance for the detection of heterogeneous myocardial iron distribution in thalassaemia patients
    in NMR in biomedicine
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Positano, V (Positano, Vincenzo)[ 1,2 ] ; Pepe, A (Pepe, Alessia)[ 1,2 ] ; Santarelli, MF (Santarelli, Maria Filomena)[ 1,2 ] ; Ramazzotti, A (Ramazzotti, Anna)[ 1,2 ] ; Meloni, A (Meloni, Antonella)[ 1,2 ] ; De Marchi, D (De Marchi, Danielle)[ 1,2 ] ; Favilli, B (Favilli, Brunella)[ 1,2 ] ; Cracolici, E (Cracolici, Eliana)[ 3 ] ; Midiri, M (Midiri, Massimo)[ 3 ] ; Spasiano, A (Spasiano, Anna)[ 4 ] ; Lombardi, M (Lombardi, Massimo)[ 1,2 ] ; Landini, L (Landini, Luigi)[ 1,2,5 ] (literal)
Pagina inizio
  • 707 (literal)
Pagina fine
  • 715 (literal)
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  • 22 (literal)
Rivista
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  • In: Nmr in Biomedicine, vol. 22 pp. 707 - 715. John Wiley & Sons, 2009. In: Nmr in Biomedicine, vol. 22 pp. 707 - 715. John Wiley & Sons, Ltd, 2009. (literal)
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  • 7 (literal)
Note
  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
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  • [ 1 ] Gabriele Monasterio Fdn, MRI Lab, I-56124 Pisa, Italy - [ 2 ] CNR, Inst Clin Physiol, I-56100 Pisa, Italy - [ 3 ] Univ Palermo, Dept Radiol, Palermo, Italy - [ 4 ] Cardarelli Hosp, Ctr Cura Microcitemie, Naples, Italy - [ 5 ] Univ Pisa, Dept Informat Engn, Pisa, Italy (literal)
Titolo
  • Multislice multiecho T2* cardiac magnetic resonance for the detection of heterogeneous myocardial iron distribution in thalassaemia patients (literal)
Abstract
  • The present study investigated myocardial T2* heterogeneity in thalassaemia major (TM) patients by cardiac magnetic resonance (CMR), to determine whether is related to inhomogeneous iron overload distribution. A total of 230 TM patients consecutively referred to our laboratory were studied retrospectively. Three short-axis views (basal, medium and apical) of the left ventricle (LV) were obtained by multislice multiecho T2* CMR. T2* segmental distribution was mapped on a 16-segment LV model. The level of heterogeneity of the T2* segmental distribution, evaluated by the coefficient of variation (CoV),was compared with that of a surrogate data set, to determinewhether the inhomogeneous segmental distribution of T2* could be generated by susceptibility artefacts. Susceptibility artefacts offer an explanation for the T2* heterogeneity observed in patientswithout iron overload. In subjectswith global T2* belowthe lower limit of the normal, T2* heterogeneity increased abruptly which could not be xplained by artefactual effects. Some segmental T2* values were below and others above the limit of normal threshold (20ms) in 104 (45%) TM patients. Among these patients, 74% showed a normal T2* global value. In conclusion, a true heterogeneity in the iron overload distribution may be present in TM patients. Heterogeneity seemingly appears in the borderline myocardial iron and stabilizes at moderate to severe iron burden. (literal)
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