Triggering DTH and CTL activity by fd filamentous bacteriophages: role of CD4+ T cells in memory responses (Articolo in rivista)

Type
Label
  • Triggering DTH and CTL activity by fd filamentous bacteriophages: role of CD4+ T cells in memory responses (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1155/2010/894971 (literal)
Alternative label
  • Del Pozzo G., Mascolo D., Sartorius R., Citro A., Barba P., D'Apice Land., De Berardinis P. (2010)
    Triggering DTH and CTL activity by fd filamentous bacteriophages: role of CD4+ T cells in memory responses
    in Journal of Biomedicine and Biotechnology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Del Pozzo G., Mascolo D., Sartorius R., Citro A., Barba P., D'Apice Land., De Berardinis P. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 2010 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • PMID: 20454650 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 6 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Genetics and Biophysics, CNR Naples, Italy; Institute of Protein Biochemistry, CNR, Naples, Italy (literal)
Titolo
  • Triggering DTH and CTL activity by fd filamentous bacteriophages: role of CD4+ T cells in memory responses (literal)
Abstract
  • The ability of fd bacteriophage particles to trigger different arms of the immune system has been previously shown by us with particular emphasis on the ability of phages to raise CTL responses in vitro and in vivo. Here we show that fd virions in the absence of adjuvants are able to evoke a DTH reaction mediated by antigen specific CD8+ T cells. In addition, we analyzed the induction of CTL responses in mice depleted of CD4+ T cells, and we observed that short-term secondary CTL responses were induced in the absence of CD4+ T cells while induction of long-termmemory CTLs required the presence of CD4+ T lymphocytes. These results examine the cellular mechanism at the basis of fd efficiency and provide new elements to further validate the use of fd particles for eliciting and monitoring antigen-specific CTLs. (literal)
Prodotto di
Autore CNR

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it