Electrospray Ionization Mass Spectrometry in the structural characterization of a mixed nitrido-Tc heterocomplex of interest for myocardial imaging (Articolo in rivista)

Type
Label
  • Electrospray Ionization Mass Spectrometry in the structural characterization of a mixed nitrido-Tc heterocomplex of interest for myocardial imaging (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/rcm.1021 (literal)
Alternative label
  • Marotta, E.; Tisato, F.; Refosco, F.; Bolzati, C.; Porchia, M.;Traldi, P. (2003)
    Electrospray Ionization Mass Spectrometry in the structural characterization of a mixed nitrido-Tc heterocomplex of interest for myocardial imaging
    in RCM. Rapid communications in mass spectrometry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Marotta, E.; Tisato, F.; Refosco, F.; Bolzati, C.; Porchia, M.;Traldi, P. (literal)
Pagina inizio
  • 1225 (literal)
Pagina fine
  • 1228 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://onlinelibrary.wiley.com/doi/10.1002/rcm.1021/abstract (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 17 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • La spettrometria ESI è stata utilizzata per la prima volta per la caratterizzazione di un complesso nitruro di Tc-99 contenente una difosfina e un ditiocarbammato. Successivi esperimenti di collisione hanno evidenziato un cammino di frammentazione che prevede la rottura di un legame Tc-P seguita da un riarrangiamento intramolecolare con formazione di un addotto penta-coordinato. (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 2,3,4,5 CNR-ICIS, Corso Stati Uniti 4, 35127 Padova, Italy 1,6 CNR-ISTM, Area di Ricerca, Corso Stati Uniti 4, 35127 Padova, Italy (literal)
Titolo
  • Electrospray Ionization Mass Spectrometry in the structural characterization of a mixed nitrido-Tc heterocomplex of interest for myocardial imaging (literal)
Abstract
  • The widespread use in diagnostic nuclear medicine of the metastable isotope 99mTc, a pure ƒ×-emitter with ideal physical properties for nuclear imaging (t1/2 = 6.06 h, Eƒ× = 140 keV), and easy availability through the commercial 99Mo/99mTc generator, and the recent advent of the ƒÒ-emitting radionuclides 186Re (t1/2 = 3.8 d, EƒÒmax = 1.07 MeV) and 188Re (t1/2 = 0.7 d, EƒÒmax = 2.11 MeV) as promising candidates for the application of injectable radiopharmaceuticals to the therapy of malignant and degenerative diseases, has made inorganic chemistry studies with the group VII elements technetium and rhenium very attractive. The focus of these investigations is the determination of the molecular structure of 99mTc- and 188/186Re-based agents produced at very low concentrations (micromolar scale or ¡¥non carrier added¡¦ level, nca). This can be conveniently achieved through the comparison of their chemical properties with those of the corresponding compounds prepared at the millimolar level (¡¥carrier added¡¦, ca) using the long-lived ƒÒ-emitting isotope 99Tc and the naturally occurring mixture of non-radioactive Re isotopes; the latter can be fully characterized by standard analytical and spectroscopic methods. Indeed, it is apparent that the possibility to clearly establish the chemical identity of a specific tracer is of utmost importance for the elucidation of its biological behavior. (literal)
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