http://www.cnr.it/ontology/cnr/individuo/prodotto/ID169185

Autosomal microsatellite and mtDNA genetic analysis in Sicily (Italy). (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Autosomal microsatellite and mtDNA genetic analysis in Sicily (Italy). (Articolo in rivista) (literal)

Anno

2003-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1046/j.1469-1809.2003.00007.x (literal)

Alternative label

Romano V; Calì F; Ragalmuto A; D'Anna RP; Flugy A; De Leo G; Giambalvo O; Lisa A; Fiorani O; Di Gaetano C; Salerno A; Tamouza R; Charron D; Zei G; Matullo G; Piazza A. (2003)
Autosomal microsatellite and mtDNA genetic analysis in Sicily (Italy).
in Annals of human genetics (Print); Cambridge University Press, Cambridge (Regno Unito)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Romano V; Calì F; Ragalmuto A; D'Anna RP; Flugy A; De Leo G; Giambalvo O; Lisa A; Fiorani O; Di Gaetano C; Salerno A; Tamouza R; Charron D; Zei G; Matullo G; Piazza A. (literal)

Pagina inizio

42 (literal)

Pagina fine

53 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://onlinelibrary.wiley.com/doi/10.1046/j.1469-1809.2003.00007.x/pdf (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

67 (literal)

Rivista

Annals of human genetics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

Impact Factor: 3.102 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

1 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Italy; Istituto OASI (I.R.C.C.S.), Troina (EN), Italy Dipartimento di Metodi Quantitativi per le Scienze Umane, Facoltà di Economia, Università di Palermo, Viale delle Scienze, Palermo, Italy; Istituto di Metodologie Diagnostiche CNR, Palermo, Italy; Dipartimento di Genetica, Biologia e Biochimica, Università di Torino, Via Santena 19, Torino, Italy; Laboratoire d'Immunologie et d'Histocompatibilite, AP-HP, IUH and INSERM U396, Paris, France; Istituto di Genetica Molecolare, CNR, Pavia, Italy (literal)

Titolo

Autosomal microsatellite and mtDNA genetic analysis in Sicily (Italy). (literal)

Abstract

DNA samples from 465 blood donors living in 7 towns of Sicily, the largest island of Italy, have been collected according to well defined criteria, and their genetic heterogeneity tested on the basis of 9 autosomal microsatellite and mitochondrial DNA polymorphisms for a total of 85 microsatellite allele and 10 mtDNA haplogroup frequencies. A preliminary account of the results shows that: a) the samples are genetically heterogeneous; b) the first principal coordinates of the samples are correlated more with their longitude than with their latitude, and this result is even more remarkable when one outlier sample (Butera) is not considered; c) distances among samples calculated from allele and haplogroup frequencies and from the isonymy matrix are weakly correlated (r = 0.43, P = 0.06) but such correlation disappears (r = 0.16) if the mtDNA haplogroups alone are taken into account; d) mtDNA haplogroups and microsatellite distances suggest settlements of people occurred at different times: divergence times inferred from microsatellite data seem to describe a genetic composition of the town of Sciacca mainly derived from settlements after the Roman conquest of Sicily (First Punic war, 246 BC), while all other divergence times take root from the second to the first millennium BC, and therefore seem to backdate to the pre-Hellenistic period. A more reliable association of these diachronic genetic strata to different historical populations (e.g. Sicani, Elymi, Siculi), if possible, must be postponed to the analysis of more samples and hopefully more informative uniparental DNA markers such as the recently available DHPLC-SNP polymorphisms of the Y chromosome. (literal)

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