Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose. (Articolo in rivista)

Type
Label
  • Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose. (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Alternative label
  • Bodrato N, Franco L, Fresia C, Guida L, Usai C, Salis A, Moreschi I, Ferraris C, Verderio C, Basile G, Bruzzone S, Scarfì S, De Flora A, Zocchi E. (2009)
    Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose.
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bodrato N, Franco L, Fresia C, Guida L, Usai C, Salis A, Moreschi I, Ferraris C, Verderio C, Basile G, Bruzzone S, Scarfì S, De Flora A, Zocchi E. (literal)
Pagina inizio
  • 14777 (literal)
Pagina fine
  • 14787 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 284 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose. (literal)
Abstract
  • Abscisic acid (ABA) is a phytohormone regulating important functions in higher plants, notably responses to abiotic stress. Recently, chemical or physical stimulation of human granulocytes was shown to induce production and release of endogenous ABA, which activates specific cell functions. Here we provide evidence that ABA stimulates several functional activities of the murine microglial cell line N9 (NO and tumor necrosis factor-alpha production, cell migration) through the second messenger cyclic ADP-ribose and an increase of intracellular calcium. ABA production and release occur in N9 cells stimulated with bacterial lipopolysaccharide, phorbol myristate acetate, the chemoattractant peptide f-MLP, or beta-amyloid, the primary plaque component in Alzheimer disease. Finally, ABA priming stimulates N9 cell migration toward beta-amyloid. These results indicate that ABA is a pro-inflammatory hormone inducing autocrine microglial activation, potentially representing a new target for anti-inflammatory therapies aimed at limiting microglia-induced tissue damage in the central nervous system. (literal)
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