http://www.cnr.it/ontology/cnr/individuo/prodotto/ID168724
Design of photosensitizer/cyclodextrin nanoassemblies:spectroscopy, intracellular delivery and photodamage (Articolo in rivista)
- Type
- Label
- Design of photosensitizer/cyclodextrin nanoassemblies:spectroscopy, intracellular delivery and photodamage (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1142/S1088424610002562 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- A. Mazzaglia; N. Micali;L. Monsù Scolaro; M.T. Sciortino; S. Sortino; V. Villari (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Scopu (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- CNR-Isituto per lo Studio dei Materiali Nanostrutturati (ISMN-CNR), 98166, Messina, Italy;CNR-Istituto per i Processi Chimico-Fisici (IPCF-CNR), , 98158, Messina, Italy; Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica and CIRCMSB, Università di Messina,
Salita Sperone 31, 98166, Messina, Italy; Dipartimento di Scienze della Vita, Sezione di Microbiologia, Genetica e Biologia Molecolare, Università di
Messina, 98166, Messina, Italy; Dipartimento di Scienze Chimiche, Università degli Studi di Catania,95125, Catania (literal)
- Titolo
- Design of photosensitizer/cyclodextrin nanoassemblies:spectroscopy, intracellular delivery and photodamage (literal)
- Abstract
- The engineering of multifunctional nanoparticles carrying photosensitizer drugs
(PS) and exposing binding groups for cellular receptors is of increasing interest in therapeutics and
diagnostics applications. Natural and modified cyclodextrins (CDs) offer useful scaffolds to bind PS
guests by supramolecular interactions. In particular, amphiphilic ?-CDs, which form nanoaggregates
of diverse shape and size according to the polarity of substituent groups on the rims, include in
their different compartments as CD cavity, hydrophilic and hydrophobic portion, PS with different
physicochemical properties. PS embedded in cationic amphiphilic CD nanoassemblies are effective in
inducing photodynamic damage in cancer cells. For a carrier/PS system to be used in photodynamic
therapy (PDT) or photodynamic diagnosis (PDD), the appropriate combination of the delivery
characteristics with the preservation of the photodynamic activity of the PS is strictly required.
Homogeneous multilayer films based on cationic amphiphilic ?-CD entrapping anionic porphyrins
can be constructed to exploit interfacial electrostatic interactions between the two components. The
capability of CDs to generate restricted microenvironments for PS which can facilitate photoinduced
energy transfer with suitable donor molecules was investigated for potential application in
fluorescence diagnosis. Besides, recent findings suggest that PDT could represent a useful tool for
properly addressing an alternative approach for killing pathogens and combating infections at a
clinical level. Finally, modified CDs can bind gold nanoparticles, yielding hybrid organic/inorganic
nanoparticles which were studied in water solution and after casting on solid substrates. These binary
assemblies could further encapsulate PS or other conventional drugs, opening new intriguing routes
on multimodal therapy. (literal)
- Prodotto di
- Autore CNR
Incoming links:
- Prodotto
- Autore CNR di
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi