Structure and dimerization of the teleost transmembrane immunoglobulin region (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Structure and dimerization of the teleost transmembrane immunoglobulin region (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.jmgm.2008.07.001 (literal)

Alternative label

• Merlino A.; Varriale S.; Coscia M.R.; Mazzarella L.; Oreste U. (2008)
  Structure and dimerization of the teleost transmembrane immunoglobulin region
  in Journal of molecular graphics & modelling
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Merlino A.; Varriale S.; Coscia M.R.; Mazzarella L.; Oreste U. (literal)

Pagina inizio

• 401 (literal)

Pagina fine

• 407 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/18760646 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 27 (literal)

Rivista

• Journal of molecular graphics & modelling (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Chemistry, University of Naples 'Federico II', Via Cinthia, I-80126, Naples, Italy Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I-80131, Naples, Italy Institute of Biostructures and Bioimages, CNR, Via Mezzocannone 16, I-80134, Naples, Italy (literal)

Titolo

• Structure and dimerization of the teleost transmembrane immunoglobulin region (literal)

Abstract

• The immune system cells express activating receptors, which consist of a dimeric ligand-binding molecule associated with a signal transducing dimer. The communication between the receptor partners depends primarily on the interactions between their membrane-embedded segments. In the B cell receptor (BCR) the sequence traversing the lipid bilayer of the immunoglobulin (IgTM) is highly conserved among species. We have investigated the association of the IgTM regions of the BCR of the Antarctic teleost Chionodraco hamatus. The nucleotide sequence of the entire immunoglobulin chain has been determined and the length, polarity, and structure of the IgTM region have been thoroughly analyzed. Structural models of the IgTM homodimer were also obtained by performing several MD simulations in a lipid bilayer using, as a starting model, two copies of the IgTM helix placed at various relative orientations and distances. Despite a certain degree of conformational heterogeneity, the predicted models of the IgTM homodimer display similar packing interfaces, characterized by a high degree of surface complementarity. The residues presumably responsible for the interaction and, consequently for the receptor stability have been identified in this manner. (literal)

Prodotto di

• Institute of protein biochemistry (IBP) (Istituto)
• DR. SSA VERDE Adattamenti evolutivi negli organismi polari (TA.P02.021.001) (Modulo)
• Determinazione della struttura tridimensionale di biomolecole complesse con tecniche spettroscopiche e cristallografiche (PM.P01.022.001) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• Lelio Mazzarella (Persona)
• UMBERTO ORESTE (Persona)
• MARIA ROSARIA COSCIA (Unità di personale interno)
• SONIA VARRIALE (Unità di personale esterno)

Insieme di parole chiave

• Parole chiave di "Structure and dimerization of the teleost transmembrane immunoglobulin region" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• UMBERTO ORESTE (Persona)
• MARIA ROSARIA COSCIA (Unità di personale interno)
• Lelio Mazzarella (Persona)
• SONIA VARRIALE (Unità di personale esterno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Institute of protein biochemistry (IBP) (Istituto)
• Determinazione della struttura tridimensionale di biomolecole complesse con tecniche spettroscopiche e cristallografiche (PM.P01.022.001) (Modulo)
• DR. SSA VERDE Adattamenti evolutivi negli organismi polari (TA.P02.021.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of molecular graphics & modelling (Rivista)

Insieme di parole chiave di

• Parole chiave di "Structure and dimerization of the teleost transmembrane immunoglobulin region" (Insieme di parole chiave)