Transcription profile of human lymphocytes following in vitro treatment with thymosin alpha-1. (Articolo in rivista)

Type
Label
  • Transcription profile of human lymphocytes following in vitro treatment with thymosin alpha-1. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1111/j.1749-6632.2010.05484.x (literal)
Alternative label
  • Matteucci C1; Minutolo A1; Sinibaldi-Vallebona P1; Palamara AT2; Rasi G3; Mastino A4; Garaci E.1 (2010)
    Transcription profile of human lymphocytes following in vitro treatment with thymosin alpha-1.
    in Annals of the New York Academy of Sciences
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Matteucci C1; Minutolo A1; Sinibaldi-Vallebona P1; Palamara AT2; Rasi G3; Mastino A4; Garaci E.1 (literal)
Pagina inizio
  • 6 (literal)
Pagina fine
  • 19 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Review.PMID: 20536445 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1194 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy; 2 Institute Pasteur, Cenci Bolognetti Foundation, Department of Public Health Sciences, University of Rome \"Sapienza,\" and IRCCS San Raffaele Pisana, Rome, Italy; 3 Institute of Neurobiology and Molecular Medicine, Department of Medicine, National Research Council, Rome, Italy; 4 Department of Life Science, Section of Microbiological, Genetic and Molecular Sciences, University of Messina, Messina, Italy (literal)
Titolo
  • Transcription profile of human lymphocytes following in vitro treatment with thymosin alpha-1. (literal)
Abstract
  • Thymosin alpha-1 (Talpha1) is a molecule retaining pleiotropic effects toward several pathological conditions, especially acting as a modulator of immune response and inflammation. However, molecular mechanisms underlying the peculiar, wide-range activity of Talpha1 have not been completely elucidated. To get information on the mechanism of action of Talpha1 and to find new potential applications, we performed the analysis of the transcription profile of 8300 genes in human peripheral blood mononuclear cells in vitro treated with Talpha1. Together with a variety of genes already known to be modulated by Talpha1, our analysis revealed a remarkable number of genes not yet described before to be modulated by this thymic peptide, revealing a complex scenario that underlines the role of this peptide as a regulator of lymphocyte functions. Here, we report the list of the more representative modulated genes and discuss their implications on the modulation of the innate and adaptive responses. Our results open new perspectives on the use of Talpha1 for the treatment of diseases associated with immune-disregulation. (literal)
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