http://www.cnr.it/ontology/cnr/individuo/prodotto/ID168352
Mitochondrial impairment induces excitotoxic death in cerebellar granule cells (Articolo in rivista)
- Type
- Label
- Mitochondrial impairment induces excitotoxic death in cerebellar granule cells (Articolo in rivista) (literal)
- Anno
- 2004-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Bobba A; Atlante A; Azzariti A; Sgaramella G; Calissano P; Marra E (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto di Biomembrane e Bioenergetica, CNR, Via Amendola 165/A, 70126 Bari;
Istituto di Neurobiologia e Medicina Molecolare, CNR, Viale Marx 15, 00137 Roma, Italy. (literal)
- Titolo
- Mitochondrial impairment induces excitotoxic death in cerebellar granule cells (literal)
- Abstract
- A close relationship links mitochondria to cell death with mitochondrial function-impairment considered a major biochemical event in the process of both apoptosis and necrosis. We have used different inhibitors of oxidative phosphorylation, i.e. mitochondrial respiratory chain and ATP synthesis inhibitors, and an uncoupler to investigate the mode of cell death caused by these compounds in cerebellar granule cells. This study shows that in cultured cerebellar granule cells either oxidative phosphorylation inhibitors or uncoupler induce an excitotoxic-like reaction which is mediated by activation of NMDA receptors and is likely due to the release of glutamate. Consistently, survival may occur if the toxic action of glutamate is prevented. (literal)
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- Autore CNR
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