Expression of serum amyloid A in chondrocytes and myoblasts differentiation and inflammation: possible role in cholesterol homeostasis. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Expression of serum amyloid A in chondrocytes and myoblasts differentiation and inflammation: possible role in cholesterol homeostasis. (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Alternative label

• Zerega B., Pagano A., Pianezzi A., Ulivi V., Camardella L., Cancedda R., Cancedda F.D. (2004)
  Expression of serum amyloid A in chondrocytes and myoblasts differentiation and inflammation: possible role in cholesterol homeostasis.
  in Matrix biology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Zerega B., Pagano A., Pianezzi A., Ulivi V., Camardella L., Cancedda R., Cancedda F.D. (literal)

Pagina inizio

• 35 (literal)

Pagina fine

• 46 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 23 (literal)

Rivista

• Matrix biology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy 2. Dipartimento di Oncologia, Biologia e Genetica Universita’ di Genova, Italy 3. Istituto di Biochimica delle Proteine, Consiglio Nazionale delle Ricerche, Napoli, Italy 4. Istituto di Bioimmagini e Fisiologia Molecolare, Consiglio Nazionale delle Ricerche, Sezione di Genova, Italy (literal)

Titolo

• Expression of serum amyloid A in chondrocytes and myoblasts differentiation and inflammation: possible role in cholesterol homeostasis. (literal)

Abstract

• Serum amyloid A (SAA) is synthesized by the liver during the acute phase. Local expression of SAA mRNA has been reported also in non-liver cells, a potential local source of SAA protein not related to the systemic acute phase response. SAA function has not been established yet. In the present study, we identified SAA as a protein expressed by chondrocytes and myoblasts in response to inflammatory stimula. In both cell systems, SAA mRNA and protein expression is strongly stimulated by bacterial lipopolysaccharide treatment. SAA mRNA expression is also enhanced during terminal differentiation of cells of the chondrogenic and myogenic lineage; mRNA is barely detectable in prechondrogenic cells and is highly expressed in differentiated hyperthrophic chondrocytes. An increased level of SAA mRNA was also observed in vivo when we compared mRNA extracted from tibiae of 10 day embryos, still fully cartilaginous, with tibiae from 18 day embryos, a stage when the endochondral ossification process has already started. p38 activation, a well-known event of the chondrogenesis signaling cascade, controls expression of SAA in cartilage following inflammatory stimuli. SAA secreted by stimulated chondrocytes is associated with cholesterol. Cholesterol is synthesized by the same chondrocytes and is also increased in inflammatory conditions. A role of SAA in cholesterol homeostasis in chondrocytes is proposed. (literal)

Prodotto di

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Institute of protein biochemistry (IBP) (Istituto)

Autore CNR

• LAURA CAMARDELLA (Unità di personale interno)
• FIORELLA DESCALZI (Persona)

Incoming links:

Autore CNR di

• LAURA CAMARDELLA (Unità di personale interno)
• FIORELLA DESCALZI (Persona)

Prodotto

• Institute of protein biochemistry (IBP) (Istituto)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Matrix biology (Rivista)