Platinum Complexes Can Inhibit Matrix Metalloproteinase Activity: Platinum- diethyl[(methylsulfinyl)methyl]phosphonate Complexes as Inhibitors of Matrix Metalloproteinases 2, 3, 9 and 12 (Articolo in rivista)

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Label
  • Platinum Complexes Can Inhibit Matrix Metalloproteinase Activity: Platinum- diethyl[(methylsulfinyl)methyl]phosphonate Complexes as Inhibitors of Matrix Metalloproteinases 2, 3, 9 and 12 (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/jm061435l (literal)
Alternative label
  • Sasanelli R., Boccarelli A., Giordano D., Laforgia M., Arnesano F., Natile G., Cardellicchio C., Capozzi M.A.M., Coluccia M. (2007)
    Platinum Complexes Can Inhibit Matrix Metalloproteinase Activity: Platinum- diethyl[(methylsulfinyl)methyl]phosphonate Complexes as Inhibitors of Matrix Metalloproteinases 2, 3, 9 and 12
    in Journal of medicinal chemistry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Sasanelli R., Boccarelli A., Giordano D., Laforgia M., Arnesano F., Natile G., Cardellicchio C., Capozzi M.A.M., Coluccia M. (literal)
Pagina inizio
  • 3434 (literal)
Pagina fine
  • 3441 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 50 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR ICCOM (literal)
Titolo
  • Platinum Complexes Can Inhibit Matrix Metalloproteinase Activity: Platinum- diethyl[(methylsulfinyl)methyl]phosphonate Complexes as Inhibitors of Matrix Metalloproteinases 2, 3, 9 and 12 (literal)
Abstract
  • Platinum complexes able to inhibit matrix metalloproteinases (MMPs) through a noncompetitive mechanism are reported for the first time in this study. [PtCl2(SMP)] and [Pt(dimethylmalonato)(SMP)], characterized by the bisphosphonate-analogue ligand diethyl[(methylsulfinyl)methyl]phosphonate (SMP), are slight inhibitors of MMP-2 (IC50 ) 258 ( 38 and 123 ( 14 íM, respectively) but markedly inhibit MMP-9 (IC50 ) 35.5 ( 6 and 17 ( 4 íM), MMP-3 (IC50 ) 5.3 ( 2.9 and 4.4 ( 2.2 íM), and MMP-12 (IC50 ) 10.8 ( 3 and 6.2 ( 1.8 íM). In contrast, cisplatin, carboplatin, and the SMP ligand are inactive, and the bisphosphonate clodronate shows a broad-spectrum inhibitory activity in the high micromolar range (mean IC50 > 200 íM). These results, along with mechanistic investigations (DNA interaction and tumor cell growth inhibition), demonstrate that ligand modifications of platinum compounds can be exploited to target also biological substrates distinct from DNA. (literal)
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