Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice (Articolo in rivista)

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  • Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Alternative label
  • Bartolomucci A. 1, 2, Bresciani E. 3, Bulgarelli I. 3, Rigamonti A.E. 4, Pascucci T. 5, Levi A. 6, Possenti R. 6,7, Torsello A. 3, Locatelli V. 3, Muller E.E. 4, Moles A. 1 (2009)
    Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice
    in Genes & nutrition
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bartolomucci A. 1, 2, Bresciani E. 3, Bulgarelli I. 3, Rigamonti A.E. 4, Pascucci T. 5, Levi A. 6, Possenti R. 6,7, Torsello A. 3, Locatelli V. 3, Muller E.E. 4, Moles A. 1 (literal)
Pagina inizio
  • 49 (literal)
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  • Epub 2009 Feb 27. (literal)
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  • 4(1) (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
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  • 1 - Institute of Neuroscience, CNR, Via del Fosso di Fiorano, 64/65, 00143 Rome, Italy; 2 - Department of Evolutionary and Functional Biology, University of Parma, Parma, Italy; 3 - Department of Experimental and Environmental Medicine and Biotechnology, and Interdepartmental Center for Bioinformatics and Proteomics, University of Milano-Bicocca, Monza, Italy; 4 - Department of Medical Pharmacology Chemotherapy and Toxicology, University of Milano, Milan, Italy; 5 - Department of Psychology, University “La Sapienza,” and I.R.C.C.S. “Fondazione Santa Lucia”, Rome, Italy; 6 - Institute of Neurobiology and Molecular Neuroscience, CNR-CERC, Rome, Italy; 7 - Department of Neuroscience, University of Roma II Tor Vergata, Rome, Italy (literal)
Titolo
  • Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice (literal)
Abstract
  • The vgf gene regulates energy homeostasis and the VGF-derived peptide TLQP-21 centrally exerts catabolic effects in mice and hamsters. Here, we investigate the effect of chronic intracerebroventricular (icv) injection of TLQP-21 in mice fed high fat diet (HFD). Fast weight-gaining mice injected with the peptide or cerebrospinal fluid were selected for physiological, endocrine, and molecular analysis. TLQP-21 selectively inhibited the increase in body weight and epididymal white adipose tissue (eWAT) weight induced by HFD in control animals despite both groups having a similar degree of hyperphagia. TLQP-21 normalized the increase in leptin and decrease in ghrelin while increasing epinephrine and epinephrine/norepinephrine ratio when compared to values in controls. Finally, HFD-TLQP-21 mice showed a selective increase of eWAT beta3-adrenergic receptor mRNA. Peroxisome-proliferator-activated-receptor-delta and hormone-sensing-lipase mRNA were also upregulated. In conclusion, chronic icv infusion of TLQP-21 prevented the early phase of diet-induced obesity despite overfeeding. These effects were paralleled by activation of catabolic pathways within the eWAT. Our results further support a role for TLQP-21 as a catabolic neuropeptide. (literal)
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