NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death (Articolo in rivista)

Type
Label
  • NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • Di Certo MG; Corbi N; Bruno T; Iezzi S; De Nicola F; Desantis A; Ciotti MT; Mattei E; Floridi A; Fanciulli M; Passananti C. (2007)
    NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death
    in Journal of cell science
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Di Certo MG; Corbi N; Bruno T; Iezzi S; De Nicola F; Desantis A; Ciotti MT; Mattei E; Floridi A; Fanciulli M; Passananti C. (literal)
Pagina inizio
  • 1852 (literal)
Pagina fine
  • 1858 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Impact Factor = 6.427 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 120 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a = CNR, Institute of Neurobiology and Molecular Medicine, Rome, Italy; b = CNR, Institute of Biology and Molecular Pathology, Rome, Italy; c = Istituto Regina Elena, Rome, Italy; d = Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy. (literal)
Titolo
  • NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death (literal)
Abstract
  • Neurotrophin receptor-interacting MAGE homolog (NRAGE) has been recently identified as a cell-death inducer, involved in molecular events driving cells through apoptotic networks during neuronal development. Recently, we have focused on the functional role of Che-1, also known as apoptosis-antagonizing transcription factor (AATF), a protein involved in cell cycle control and gene transcription. Increasing evidence suggests that Che-1 is involved in apoptotic signalling in neural tissues. In cortical neurons Che-1 exhibits an anti-apoptotic activity, protecting cells from neuronal damage induced by amyloid beta-peptide. Here, we report that Che-1 interacts with NRAGE and that an EGFP-NRAGE fusion protein inhibits nuclear localization of Che-1, by sequestering it within the cytoplasmic compartment. Furthermore, NRAGE overexpression downregulates endogenous Che-1 by targeting it for proteasome-dependent degradation. Finally, we propose that Che-1 is a functional antagonist of NRAGE, because its overexpression completely reverts NRAGE-induced cell-death. (literal)
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