Structural and ultrastructural localization of NGF and NGF receptors in the thymus of subjects affected by myasthenia gravis (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Structural and ultrastructural localization of NGF and NGF receptors in the thymus of subjects affected by myasthenia gravis (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1080/08916930400016717 (literal)

Alternative label

• Marinova T.T.1; Velikova K.K.2; Petrov D.B.3; Kutev N.S.3; Stankulov I.S.4; Chaldakov G.N.4; Triaca V.5; Manni L.5; Aloe L.5 (2004)
  Structural and ultrastructural localization of NGF and NGF receptors in the thymus of subjects affected by myasthenia gravis
  in Autoimmunity (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Marinova T.T.1; Velikova K.K.2; Petrov D.B.3; Kutev N.S.3; Stankulov I.S.4; Chaldakov G.N.4; Triaca V.5; Manni L.5; Aloe L.5 (literal)

Pagina inizio

• 587 (literal)

Pagina fine

• 592 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 37 (literal)

Rivista

• Autoimmunity (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 8 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Department of Medical Biology, Medical University, Sofia, Bulgaria; 2 Department of General and Clinical Pathology, Medical University, Sofia, Bulgaria; 3 Department of Surgery, Medical University, Sofia, Bulgaria; 4 Division of Cell Biology, Department of Forensic Medicine, Medical University, Varna, Bulgaria; 5 Institute of Neurobiology and Molecular Medicine, CNR, Viale Marx, 43/15 00137, Rome, Italy (literal)

Titolo

• Structural and ultrastructural localization of NGF and NGF receptors in the thymus of subjects affected by myasthenia gravis (literal)

Abstract

• We have previously reported that the thymus of patients affected by myasthenia gravis (MG) is characterized by an elevated level of nerve growth factor (NGF), an endogenous polypeptide which plays a marked role in the cell biology of nervous and immune system. A consistent number of studies has shown altered expression of NGF in diseases associated with inflammatory and/or autoimmune responses. To evaluate the biochemical and molecular mechanisms implicated in NGF action in human myasthenic thymus, it is important to identify the cellular and structural organization of NGF receptors. To address this question, we investigated, both at light and electron microscopic levels, the cellular distribution of immunoreactivity for NGF and its low-affinity receptors, (p75) and its high-affinity receptor (TrkA) in the thymus of patients with MG. The present investigation shows that NGF and NGF receptors are overexpressed in the thymic cells of patients with MG compared to control subjects. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Funzioni del S.N./Neurotrofine (SV.P16.007.001) (Modulo)

Autore CNR

• LUIGI ALOE (Unità di personale interno)
• LUIGI MANNI (Persona)

Incoming links:

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Funzioni del S.N./Neurotrofine (SV.P16.007.001) (Modulo)

Autore CNR di

• LUIGI ALOE (Unità di personale interno)
• LUIGI MANNI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Autoimmunity (Rivista)